| Identification | Back Directory | [Name]
FAUC 213 | [CAS]
337972-47-1 | [Synonyms]
FAUC213 FAUC-213 Pyrazolo[1,5-a]pyridine, 2-[[4-(4-chlorophenyl)-1-piperazinyl]methyl]- inhibit,p5-HT2,FAUC 213,orally,pα1,BBB,AMPH,barrier,amphetamin,blood-brain,Inhibitor,Dopamine Receptor,p5-HT1,antipsychotic | [Molecular Formula]
C18H19ClN4 | [MDL Number]
MFCD06798338 | [MOL File]
337972-47-1.mol | [Molecular Weight]
326.82 |
| Hazard Information | Back Directory | [Uses]
FAUC 213 is a highly selective D4 dopamine receptor full antagonist. | [in vivo]
FAUC 213 (7.5-30 mg/kg; orally; single dose) significantly reduces this elevation in AMPH-induced locomotor hyper-activity only pre-treatment with 30 mg/kg. FAUC 213 significantly restores the prepulse inhibition (PPI) reduction caused by the apomorphine (APO) treatment with 30 mg/kg[1].
| Animal Model: | Male adult Wistar rats weighing 300-350 g[1] | | Dosage: | 7.5, 15, 30 mg/kg | | Administration: | Orally; single dose | | Result: | Significantly reduced this elevation in amphetamin (AMPH)-induced locomotor hyper-activity only pre-treatment with 30 mg/kg.
|
| [IC 50]
hD4.4 Receptor: 2.2 nM (Ki); hD2 Receptor: 3.4 μM (Ki); hD3 Receptor: 5.3 μM (Ki) |
|
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
|