| Identification | Back Directory | [Name]
FAUC-365 | [CAS]
474432-66-1 | [Synonyms]
FAUC-365
3-dichloro-
FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2
FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro-
phenyl)-piperazin-1-yl]-butyl}-amide | [Molecular Formula]
C23H25Cl2N3OS | [MDL Number]
MFCD28160534 | [MOL File]
474432-66-1.mol | [Molecular Weight]
462.435 |
| Chemical Properties | Back Directory | [Boiling point ]
680.3±55.0 °C(Predicted) | [density ]
1.300±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
insoluble in EtOH; insoluble in H2O; ≥5.79 mg/mL in DMSO | [form ]
A crystalline solid | [pka]
14.55±0.46(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
FAUC-365 is a dopamine D3 receptor antagonist (Ki = 0.5 nM). It is selective for dopamine D3 receptors over dopamine D1, D2L, D2S, and D4 receptors (Kis = 8.8, 3.6, 2.6, and 0.34 μM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2 (Kis = 0.36 and 2 μM, respectively). FAUC-365 (1-10 mg/kg) prevents memory impairment in the novel object recognition test in dopamine transporter knockdown (DAT-KD) mice when administered prior to object learning. | [Uses]
FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2]. | [in vitro]
fauc-365 was discovered by a rational and interactive sar sequence. as a dichloro derivative, fauc-365 revealed d3 affinities that were comparable to its methoxy-substituted analogues, however, the selectivities of fauc-365 against 5ht-1a, 5-ht2, and r1 were substantially higher, which was demonstrated by that extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over d1, d2long, d2short, and d4, respectively, were determined for fauc-365 with ki of 0.50 nm. in addition, the benzothiophene analog fauc 346 and its oxa analogue showed partial agonist character with ec50 values at 0.36 and 1.5 nm, respectively [1]. | [storage]
Store at -20°C | [References]
[1] bettinetti l, schlotter k, hübner h, gmeiner p. interactive sar studies: rational discovery of super-potent and highly selective dopamine d3 receptor antagonists and partial agonists. j med chem. 2002 oct 10;45(21):4594-7. |
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| Company Name: |
Lynnchem
|
| Telephone: |
86-(0)29-85992781 17792393971 |
| Website: |
http://www.lynnchem.com/ |
| Company Name: |
InvivoChem
|
| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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