| Identification | Back Directory | [Name]
LY 456236 | [CAS]
338736-46-2 | [Synonyms]
(4-Methoxy-phenyl)-(6-methoxy-quinazolin-4-yl)-amine hydrochloride | [Molecular Formula]
C16H16ClN3O2 | [MDL Number]
MFCD08703117 | [MOL File]
338736-46-2.mol | [Molecular Weight]
317.77 |
| Hazard Information | Back Directory | [Uses]
LY 456236 is a mGlu1 receptor antagonists, which may be used in the treatment of chronic pain and epilepsy and other seizure disorders. | [in vivo]
LY456236 shows anticonvulsant effects in mice (3-100 mg/kg; i.p.; once) and rats (10-60 mg/kg; oral; once)[3]. | Animal Model: | DBA/2 mice and CD1 mice, seizure models[3] | | Dosage: | 3-100 mg/kg | | Administration: | IP, once | | Result: | Produced dose-related anticonvulsant effects in preventing audiogenic-induced (tonic-clonic) seizures in DBA/2 mice, threshold electroshock-induced seizures in CD1 mice, and 6 Hz electroshock-induced seizures in CD1 mice. |
| Animal Model: | Amygdala-kindled Sprague-Dawley rats[3] | | Dosage: | 10, 30 and 60 mg/kg | | Administration: | Oral, once | | Result: | Produced dose-related decreases in behavioral and electrographic seizures at threshold stimulus intensity. Produced a dose-related increase in the stimulus intensity required to produce generalized seizures. |
| [storage]
Desiccate at RT |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|