| Identification | Back Directory | [Name]
2-HEPTYL-4-HYDROXYQUINOLINE N-OXIDE | [CAS]
341-88-8 | [Synonyms]
hqno
kf8940
Pyo II
C04284
Antibiotic KF-8940
NZPACTGCRWDXCJ-UHFFFAOYSA-N
2-heptyl-4-quinolino1-oxide
2-Heptylquinolin-4-ol 1-oxide
2-(n-heptyl)-4-hydroxyquinolinen-oxide | [Molecular Formula]
C16H19NO2 | [MDL Number]
MFCD00057295 | [MOL File]
341-88-8.mol | [Molecular Weight]
257.328 |
| Chemical Properties | Back Directory | [Melting point ]
156-157° | [Boiling point ]
445.8±37.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C | [solubility ]
Soluble in DMSO (up to 8 mg/ml with warming), or in Ethanol (up to 13 mg/ml with warming). | [form ]
White to off-white crystalline solid. | [pka]
1.07±0.40(Predicted) | [color ]
White | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
HQNO (341-88-8) is a naturally occurring antagonist of dihydrostreptomycin. Potent inhibitor of the respiratory chain binding to the mitochondrial cytochrome b protein. HQNO inhibits NADH oxidase (NADH) and Na+-dependent NADH-quinone reductase (NQR). | [Uses]
HQNO is a streptomycin antagonist. A naturally occurring antagonist of dihydrostreptomycin. | [Definition]
ChEBI: 2-heptyl-4-hydroxyquinoline N-oxide is an inhibitor of the mitochondrial respiratory chain at cytochrome bc1 and of photosynthetic electron flow immediately before cytochrome b559. It is a monohydroxyquinoline and a quinoline N-oxide. | [References]
References/Citations
1) Nakayama?et al. (1999),?Inhibitor studies of a new antibiotic, korormicin, 2-n-heptyl-4-hydroxyquinoline N-oxide and Ag+?toward the Na+-translocating NADH-quinone reductase from the marine Vibrio alginolyticus; Biol. Pharm. Bull.,?221064 |
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| Company Name: |
Rhawn Reagent
|
| Tel: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
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