| Identification | Back Directory | [Name]
ANGIOTENSIN I/II (5-8) | [CAS]
34233-50-6 | [Synonyms]
IHPF
ILE-HIS-PRO-PHE
H-ILE-HIS-PRO-PHE-OH
ANGIOTENSIN II (5-8)
ANGIOTENSIN I/II (5-8)
ANGIOTENSIN II (5-8), HUMAN
Angiotensin II (5-8) (human, rat, mouse)
Angiotensin I/II (5-8) H-Ile-His-Pro-Phe-OH
(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoicacid | [Molecular Formula]
C26H36N6O5 | [MDL Number]
MFCD00167499 | [MOL File]
34233-50-6.mol | [Molecular Weight]
512.6 |
| Chemical Properties | Back Directory | [Boiling point ]
915.4±65.0 °C(Predicted) | [density ]
1.286±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
3.56±0.10(Predicted) | [color ]
White to off-white | [Sequence]
H-Ile-His-Pro-Phe-OH |
| Hazard Information | Back Directory | [Uses]
Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[2][3]. | [Definition]
ChEBI: Angiotensin (5-8) is a dichlorobenzene. | [References]
[1] Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27. DOI:10.1016/j.neuroscience.2012.11.048
[2] De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. DOI:10.3389/fphys.2013.00411
[3] Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5. DOI:10.5049/EBP.2013.11.2.41 |
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