| Identification | Back Directory | [Name]
L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- | [CAS]
812644-79-4 | [Synonyms]
TRV056
L-Phenylalanine, L-α-aspartyl-L-arginylglycyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl- | [Molecular Formula]
C52H74N14O13 | [MDL Number]
MFCD34471292 | [MOL File]
812644-79-4.mol | [Molecular Weight]
1103.25 |
| Hazard Information | Back Directory | [Uses]
TRV056 is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV056 is efficacious in stimulating cellular Gq-mediated signaling. TRV056 can be used to develop the Gq-biased AT1R agonists[1]. | [IC 50]
AT1 Receptor | [References]
[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005 |
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