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342595-05-5

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342595-05-5 Structure

342595-05-5 Structure
IdentificationBack Directory
[Name]

TM5007
[CAS]

342595-05-5
[Synonyms]

TM5007
[2,3'-Bithiophene]-4'-carboxylic acid, 5',5'''-[(1,6-dioxo-1,6-hexanediyl)diimino]bis-
[Molecular Formula]

C24H20N2O6S4
[MOL File]

342595-05-5.mol
[Molecular Weight]

560.69
Chemical PropertiesBack Directory
[Boiling point ]

781.7±60.0 °C(Predicted)
[density ]

1.544±0.06 g/cm3(Predicted)
[pka]

3.93±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung[1].
[References]

[1] Izuhara Y, et al. Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):672-7. DOI:10.1161/ATVBAHA.107.157479
Spectrum DetailBack Directory
[Spectrum Detail]

TM5007(342595-05-5)1HNMR
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