| Identification | More | [Name]
2-Bromo-5-chlorobenzotrifluoride | [CAS]
344-65-0 | [Synonyms]
2-BROMO-5-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE
2-BROMO-5-CHLOROBENZOTRIFLUORIDE
Benzene,2-bromo-5-chloro-1-(trifluoromethyl)-
2-bromo-5-chloro-α,α,α-trifluorotoluene
2-Bromo-5-chlorobenzotrifluoride 99%
2-Bromo-5-chlorobenzotrifluoride99%
2-BROMO-5-CHLOROBENZOTRIFLUORIDE, 98+%
1-Bromo-4-chloro-2-(trifluoromethyl)benzene | [EINECS(EC#)]
608-994-3 | [Molecular Formula]
C7H3BrClF3 | [MDL Number]
MFCD00010308 | [Molecular Weight]
259.45 | [MOL File]
344-65-0.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colourless to slightly yellow liquid | [Melting point ]
18-20°C | [Boiling point ]
179-180 °C (lit.) | [density ]
1.759 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.5080(lit.)
| [Fp ]
198°C | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Colorless to Almost colorless | [BRN ]
2448030 | [CAS DataBase Reference]
344-65-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colourless to slightly yellow liquid | [Uses]
2-Bromo-5-chlorobenzotrifluoride was used in preparation of 6-[4-chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine and 4,4′-dichloro-2,2′-bis(trifluoromethyl) diphenyl sulphone. | [Synthesis]
The general procedure for synthesizing 2-bromo-5-chlorobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: a diazonium salt solution was prepared according to the method described in Example 3. The cooled diazonium salt solution was slowly added to a pre-stirred and cooled mixture of CuCl (8.9 g, 0.091 mol) dissolved in concentrated hydrochloric acid (46 g, 0.44 mol). The reaction system was kept at a low temperature and when the addition was completed, it was gradually warmed up to room temperature with continuous stirring for 2 to 3 hours. Subsequently, the reaction mixture was heated to 60-70 °C to ensure complete reaction. Upon completion of the reaction, the target product 2-bromo-5-chlorobenzotrifluoride was obtained by isolation by appropriate methods. Yield: 65%. | [References]
[1] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 8
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 3034 |
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