| Identification | Back Directory | [Name]
6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid | [CAS]
345952-44-5 | [Synonyms]
MM 11253
MM11253 >=98% (HPLC)
6-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dithiolan-2-yl]-2-naphthalenecarboxylicacid
6-[2-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dithiolan-2-yl]naphthalene-2-carboxylic acid | [Molecular Formula]
C28H30O2S2 | [MDL Number]
MFCD19690917 | [MOL File]
345952-44-5.mol | [Molecular Weight]
462.67 |
| Chemical Properties | Back Directory | [Boiling point ]
607.8±55.0 °C(Predicted) | [density ]
1.202 | [storage temp. ]
Desiccate at RT | [solubility ]
DMSO: 30 mg/ml | [form ]
A solid | [pka]
4.12±0.30(Predicted) | [color ]
Off-white to light yellow | [InChI]
1S/C28H30O2S2/c1-26(2)11-12-27(3,4)24-17-22(9-10-23(24)26)28(31-13-14-32-28)21-8-7-18-15-20(25(29)30)6-5-19(18)16-21/h5-10,15-17H,11-14H2,1-4H3,(H,29,30) | [InChIKey]
DPVGXUNWCVEIGT-UHFFFAOYSA-N | [SMILES]
OC(C1=CC(C=CC(C2(SCCS2)C3=CC(C(C)(C)CCC4(C)C)=C4C=C3)=C5)=C5C=C1)=O |
| Hazard Information | Back Directory | [Uses]
MM-11253 is a synthetic retinoid and a selective RARγ antagonist. | [Biological Activity]
MM11253 (SR11253) is a high-affinity RARγ-selective retinoid acid (RA) receptor antagonist (IC50 = 44 nM against ATRA for binding RARγ; IC50 =1 μM in case of RARαRARβRXRα) th at prevents >90% growth inhibitory effect of retinoids AHPN/CD437 (1 μM in CA-OV3 & SK-SKOV3 cultures) and M11389 (1 μM in SCC-25 squamous cell carcinoma cultures) when used at equal concentration. MM11253 also effectively blocks the inhibitory effect of R667 (RARγ agonist) against IL-1β-induced MMP production from rabbit corneal fibroblasts (80% vs. 11% inhibition by 0,1 nM R667respectivelywithout or with 0.03 nM MM11253). | [storage]
Store at -20°C |
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| Company Name: |
Energy Chemical
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| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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