| Identification | Back Directory | [Name]
D-69491 | [CAS]
346599-65-3 | [Synonyms]
D-69491
SU-11464
D69491; SU 11464; SU11464; D 69491
5-[[4-[(3-Chloro-4-fluorophenyl)amino]-6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-5-ylidene]methyl]-4-methyl-N-[2-(4-morpholinyl)ethyl]-1H-pyrrole-2-carboxamide hydrochloride | [Molecular Formula]
C25H26Cl2FN7O3 | [MOL File]
346599-65-3.mol | [Molecular Weight]
562.43 |
| Hazard Information | Back Directory | [Uses]
D-69491 hydrochloride is a HER-2 tyrosine kinase inhibitor that reduces HER-2 phosphorylation, inhibits the proliferation of SKOV-3 cells, and has anticancer activity[1]. | [IC 50]
HER2 | [References]
[1] Shaker Abuharbeid, et al. Inhibition of HER-2 by three independent targeting strategies increases paclitaxel resistance of SKOV-3 ovarian carcinoma cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Feb;371(2):141-51. DOI:10.1007/s00210-004-1016-4 |
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TargetMol
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