| Identification | Back Directory | [Name]
Benzo[a]phenazine-11-carboxamide, N-[(1R)-2-(dimethylamino)-1-methylethyl]-4-methoxy- | [CAS]
346689-77-8 | [Synonyms]
MLN576
MLN-576
MLN 576
XR11576
XR-11576
XR 11576
Benzo[a]phenazine-11-carboxamide, N-[(1R)-2-(dimethylamino)-1-methylethyl]-4-methoxy- | [Molecular Formula]
C23H24N4O2 | [MOL File]
346689-77-8.mol | [Molecular Weight]
388.46 |
| Hazard Information | Back Directory | [Uses]
XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC50: 6-47 nM)[1]. | [References]
[1] Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60. DOI:10.1097/00001813-200410000-00005
[2] Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. DOI:10.1097/00001813-200201000-00002 |
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