| Identification | Back Directory | [Name]
METHYL 2-AMINO-6-FLUORO-3-NITROBENZOATE
| [CAS]
346691-23-4 | [Synonyms]
METHYL 2-AMINO-6-FLUORO-3-NITROBENZOATE
2-Amino-6-fluoro-3-nitro-benzoic acid methyl ester
Benzoic acid, 2-amino-6-fluoro-3-nitro-, methyl ester | [Molecular Formula]
C8H7FN2O4 | [MDL Number]
MFCD09839221 | [MOL File]
346691-23-4.mol | [Molecular Weight]
214.15 |
| Chemical Properties | Back Directory | [Boiling point ]
360.9±42.0 °C(Predicted) | [density ]
1.470±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
crystalline solid | [pka]
-3.91±0.25(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of methyl 2-amino-6-fluoro-3-nitrobenzoate from methyl 2,6-difluoro-3-nitrobenzoate: Methyl 2,6-difluoro-3-nitrobenzoate (32.55 g, 150 mmol) was dissolved in ethanol (300 mL), followed by the addition of ammonia (13 mL). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the resulting yellow solid product methyl 2-amino-6-fluoro-3-nitrobenzoate (18.31 g, 57% yield) was collected by filtration. | [References]
[1] Patent: CN104003979, 2016, B. Location in patent: Paragraph 0385; 0388; 0389
[2] Patent: CN103923088, 2016, B. Location in patent: Paragraph 0214; 0216; 0219; 01220
[3] Patent: WO2009/134850, 2009, A1. Location in patent: Page/Page column 16
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2620 - 2623
[5] Patent: US2010/305133, 2010, A1. Location in patent: Page/Page column 12 |
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