| Identification | Back Directory | [Name]
1,1,3-Tribromoacetone | [CAS]
3475-39-6 | [Synonyms]
JACS-3475-39-6
1,1,3-TribromoAceton
1,1,3-tribromoacetone
1,1,3-Tribromopropan-2-one
2-Propanone,1,1,3-tribromo- | [Molecular Formula]
C3H3Br3O | [MDL Number]
MFCD09264311 | [MOL File]
3475-39-6.mol | [Molecular Weight]
294.77 |
| Chemical Properties | Back Directory | [Melting point ]
28-29 °C | [Boiling point ]
114-116 °C(Press: 14 Torr) | [density ]
2.561±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (339.25 mM; Need ultrasonic) | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C3H3Br3O/c4-1-2(7)3(5)6/h3H,1H2 | [InChIKey]
FNYCCOFOQIUTIM-UHFFFAOYSA-N | [SMILES]
C(Br)(Br)C(=O)CBr |
| Hazard Information | Back Directory | [Chemical Properties]
White or light yellow solid | [Uses]
1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
| [Synthesis]
150 g of bromine dissolved in 500 ml of glacial acetic acid are added dropwise to a solution containing 210 g of 1,3-dibromoacetone in 500 ml glacial acetic acid at 80-90° C during one hour without additional heating. When the reaction is complete the acetic acid is removed and a forerun in a vacuum afford 180 g of 1,1,3-tribromoacetone (b.p. 114-116/14 mm), and 21 g of 1,1,1,3-tetrabromoacetone (b.p. 132-133°/13 mm).
| [storage]
Store at -20°C |
|
| Company Name: |
Eastbang Pharmaceuticals Technology Co., Ltd.
|
| Telephone: |
+86 (20) 28996708,29078958,28139708,29076128,28133708,28139728,28139738,28133718,021-31663278,021-31663578,021-60538387 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList13633/0_EN.htm |
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