| Identification | Back Directory | [Name]
Methotrexate disodium salt | [CAS]
7413-34-5 | [Synonyms]
mtxdisodium
METHOTREXATUM
l-(+)-isodiumsal
amethopterinsodium
sodium methotrexate
disodiummethotrexate
METHOTREXATE DISODIUM
Methotrexatedisodiumsal
METHOTREXATE DISODIUM SALT
Methotrexate disodium salt USP/EP/BP
Methotrexate Disodium Salt Solution
4-amino-n(sup10)-methylpteroylglutamicaciddisodiumsalt
Disodium N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamate
2-[4-[(2,4-diaminopteridin-6-yl)methyl-methyl-amino]benzoyl]aminopentanedioic acid
L-Glutamic acid, N-4-(2,4-diamino-6-pteridinyl)methylmethylaminobenzoyl-, disodium salt
Sodium (S)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioate
(+)-N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
(+)-N-[4-[[(2,4-Diaminopteridine-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid disodium salt
L-GlutaMic acid,N-[4-[[(2,4-diaMino-6-pteridinyl)Methyl]MethylaMino]benzoyl]-, sodiuM salt(1:2) | [EINECS(EC#)]
231-022-0 | [Molecular Formula]
C20H20N8Na2O5 | [MDL Number]
MFCD00274560 | [MOL File]
7413-34-5.mol | [Molecular Weight]
498.4 |
| Chemical Properties | Back Directory | [Boiling point ]
823℃ | [RTECS ]
MA1232000 | [storage temp. ]
0-6°C | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
Powder | [color ]
Light yellow to yellow | [Water Solubility ]
Soluble in water | [Sensitive ]
Hygroscopic | [InChIKey]
MSDCZRQHAGWZSH-NVZXTOETNA-N | [SMILES]
NC1=NC(N)=NC2N=CC(CN(C3C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=3)C)=NC1=2.[NaH] |&1:19,r| |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301 | [Precautionary statements ]
P264-P270-P301+P310a-P321-P405-P501a | [WGK Germany ]
WGK 3 | [HazardClass ]
6.1 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2
Muta. 2
Repr. 1B
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
Inhibits the metabolism of folic acid | [Definition]
ChEBI: Methotrexate disodium is an organic sodium salt that is the disodium salt of methotrexate. It has a role as an EC 1.5.1.3 (dihydrofolate reductase) inhibitor. It contains a methotrexate(2-). | [Biological Activity]
Methotrexate disodium salt is a potent is a folic acid antagonist th at is used as an antineoplastic and antirheumatic drug. Methotrexate disodium salt is a potent inhibitor of dihydrofolate reductase. | [in vivo]
Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].
Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4]. | [IC 50]
Traditional Cytotoxic Agents |
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