| Identification | Back Directory | [Name]
NYSTATIN A1 TRIHYDRATE | [CAS]
34786-70-4 | [Synonyms]
nystatin A1
NYSTATIN A1 TRIHYDRATE USP/EP/BP
NYSTATIN A1, TRIHYDRATE VETRANAL, 250
Amphotericin B, 8,9-dideoxy-28,29-dihydro-7,10-dihydroxy-, (7R,10R)- | [Molecular Formula]
C47H75NO17.3H2O | [MDL Number]
MFCD00167103 | [MOL File]
34786-70-4.mol | [Molecular Weight]
980.144 |
| Chemical Properties | Back Directory | [Melting point ]
>300°C | [Boiling point ]
1132.2±65.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly) | [form ]
Solid | [pka]
3.72±0.70(Predicted) | [color ]
Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow powder. Contains three biologically active components: A1, A2, and A3, with strong reducing properties. The suspension is stable at 100°C for 10 minutes at pH 7.0, but decomposes rapidly under light, heat, and oxygen. It has no melting point and decomposes upon heating above 160°C. Its specific optical rotations [α]25D are +21° (pyridine), +12° (dimethylformamide), -7° (0.1 mol/L hydrochloric acid in methanol), and -10° (glacial acetic acid). Its maximum absorption wavelengths in ethanol are 290 nm, 307 nm, and 322 nm. Solubility at room temperature: 4 mg/ml in water, 11.2 mg/ml in methanol, 1.2 mg/ml in ethanol, 8.75 mg/ml in ethylene glycol, 1.23 mg/ml in carbon tetrachloride, 0.48 mg/ml in chloroform, and 0.28 mg/ml in benzene. LD50 (mouse, intraperitoneal) approximately 200 mg/kg. | [Uses]
Nystatin is a polyene macrolide antibiotic, an anti-fungal agent or anti-fungal macrolide. | [Definition]
ChEBI: Nystatin A1 is a polyene macrolide antibiotic; part of the nystatin complex produced by several Streptomyces species. It is an antifungal antibiotic used for the treatment of topical fungal infections caused by a broad spectrum of fungal pathogens comprising yeast-like and filamentous species. |
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| Company Name: |
SIGMA-RBI
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800 736 3690 (Orders) |
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www.sigma-aldrich.com |
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