| Identification | Back Directory | [Name]
8-Isoquinolinol | [CAS]
3482-14-2 | [Synonyms]
8-Isoquinolinol
Isoquinolin-8-ol
Isoquinoline-8-ol
2H-isoquinolin-8-one
8-Isoquinolinol,>97%
8-Hydroxyisoquinoline
8-Hydroxyisoquinoline95%
8-Hydroxyisoquinoline 96%
8-Isoquinolinol(6CI,7CI,8CI,9CI)
8-Isoquinolinol ISO 9001：2015 REACH
Isoquinolin-8-ol, 8-Hydroxy-2-azanaphthalene | [EINECS(EC#)]
805-508-3 | [Molecular Formula]
C9H7NO | [MDL Number]
MFCD00661583 | [MOL File]
3482-14-2.mol | [Molecular Weight]
145.16 |
| Chemical Properties | Back Directory | [Melting point ]
213 °C | [Boiling point ]
332.1±15.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
claggy powder | [pka]
8.40±0.10(Predicted) | [color ]
Light brown |
| Hazard Information | Back Directory | [Synthesis]
2-Methoxybenzaldehyde and 2,2-dimethoxyethylamine react in benzene to form an aldehyde-amine condensation reaction, which then reacts with ethyl chloroformate and trimethyl phosphite to generate 8-methoxyisoquinolin-4(3H)-one intermediate Chemicalbook. The intermediate is refluxed and dehydrated with titanium tetrachloride in dichloromethane to generate the intermediate 8-methoxyisoquinoline, which is then demethylated with boron tribromide in dichloromethane at low temperature to generate Isoquinolin-8-ol (8-Hydroxyisoquinoline).
| [References]
[1] Patent: CN106966977, 2017, A. Location in patent: Paragraph 0016; 0018-0019 |
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