| Chemical Properties | Back Directory | [density ]
2.52±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C, protect from light, stored under nitrogen | [form ]
Solid | [pka]
0.97±0.50(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water: 160 mg/mL (320.54 mM) |
| Hazard Information | Back Directory | [Uses]
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) (HY-125033) as a triphosphate form[1]. NHC-triphosphate is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. | [References]
[1] Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54. DOI:10.1128/AAC.47.1.244-254.2003
[2] Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. DOI:10.1128/AAC.02395-16 |
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