| Identification | Back Directory | [Name]
Epoprostenol | [CAS]
35121-78-9 | [Synonyms]
PGX
PGl2
U 53217
U-53217A
Vasocyclin
Cyclo-Prostin
ProstaglandinI
Prostaglandin X
Prostaglandin l2
PGX(prostaglandin)
Epoprostenol USP/EP/BP
Prostacyclin (Epoprostenol)
5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA
6(9)-Oxy-11,15-dihydroxyprosta-5,13-dienoic acid
(5Z，9α，11α，13E，15S)-6，9-Epoxy-11，15-dihydroxyprosta-5，13-dien-1-oicacid
(5z,13e)-(15s)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate
5-[7-hydroxy-8-(3-hydroxyoct-1-enyl)-4-oxabicyclo[3.3.0]oct-3-ylidene]pentanoic acid | [Molecular Formula]
C20H31O5.Na | [MOL File]
35121-78-9.mol | [Molecular Weight]
374.45 |
| Hazard Information | Back Directory | [Chemical Properties]
It is unstable in aqueous solution and hydrolyzes to form 6-oxo-PGF1α. Its half-life is approximately 14.5 minutes (at 4°C) at 0.165 mol/L of the phosphate ester. Epoprostenol Sodium: C20H31NaO5 [61849-14-7]. A hygroscopic, free-flowing white powder. It can be stored at -30°C and kept dry for 2 months. | [Originator]
Prostacyclin,ZYF Pharm Chemical | [Uses]
Inhibitor (platelet). [Names previously used:
Prostacyclin, PGI2, Prostagland in I2, Prostaglandin X,
PGX]. | [Definition]
ChEBI: Prostaglandin I2 is a prostaglandins I. It has a role as a mouse metabolite. It is a conjugate acid of a prostaglandin I2(1-). | [Manufacturing Process]
Preparation of prostacyclin:
Pig aortas were stripped of adventitia, snap frozen in liquid nitrogen, crushed
into a fine powder, resuspended in 0.05 M Tris buffer (pH 7.5) (1:4, w:v) andhomogenised at high speed in a Polytron (KIMENATIC, LUCERNE,
SWITZERLAND) homogenizer. The homogenate was centrifuged for 15 min
and the resulting supernatant centrifuged again for 5 min. The pellet was
discarded, while the pellet obtained after centrifugation of the supernatant
was resuspended in deionized water and lyophilized. An average yield of 150
mg of aortic microsomal powder (51% protein) per 100 g of aortic tissue was
obtained. | [Brand name]
Flolan (GlaxoSmithKline). | [Therapeutic Function]
Platelet aggregation inhibitor, Antimetastatic |
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