| Identification | More | [Name]
5-AMINO-1-ETHYLPYRAZOLE | [CAS]
3528-58-3 | [Synonyms]
AKOS B024267
TIMTEC-BB SBB005554
ART-CHEM-BB B024267
5-Amino-1-ethylpyrazol
1-ethy-pyrazol-5-aMine
2-ethyl-3-pyrazolamine
2-ethylpyrazol-3-amine
1-Ethyl-5-aMinopyrazole
2-Ethyl-3-aMinopyrazole
5-AMINO-1-ETHYLPYRAZOLE
2-Amino-1-ethylpyrazole
1-ETHYL-1H-PYRAZOL-5-AMINE
(2-ethylpyrazol-3-yl)amine
5-Amino-1-ethyl-1H-pyrazole
2-ETHYL-2H-PYRAZOL-3-YLAMINE
1H-Pyrazol-5-aMine, 1-ethyl- | [Molecular Formula]
C5H9N3 | [MDL Number]
MFCD00010849 | [Molecular Weight]
111.15 | [MOL File]
3528-58-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
52-57 °C (lit.) | [Boiling point ]
92-94 °C/0.01 mmHg (lit.) | [density ]
1.0671 (rough estimate) | [refractive index ]
1.5340 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [form ]
solid | [pka]
4.18±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid | [CAS DataBase Reference]
3528-58-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT | [HS Code ]
2933998090 |
| Hazard Information | Back Directory | [Uses]
5-Amino-1-ethylpyrazole is a heterocyclic building block, has been used in the preparation of 1-protected-1H-pyrazolo[3,4-b]pyridines. | [Synthesis]
1. Hydrazine hydrate (98.7 g, 1.97 mol) was slowly added dropwise to a solution of 2-acrylonitrile (100 g, 1.88 mol) in tetrahydrofuran (350 ml) at 0-5 °C. 2. The reaction mixture was stirred at room temperature for 3 h. 3. Acetaldehyde (86.9 g, 1.9 mol) was slowly added dropwise to the above mixture, and stirring was continued for 3 h at room temperature. 4. The solvent was removed by distillation under reduced pressure to give a yellow oil. 5. The oil was dissolved in n-butanol (100 ml), followed by addition of a solution of n-butanol (250 ml) containing potassium tert-butanolate (221 g, 1.9 mol). 6. The reaction mixture was gradually heated from room temperature to 120 °C and maintained at this temperature for 3 h. 7. After completion of the reaction, the reaction was cooled to room temperature, and diluted with water (500 ml). 8. ) for dilution. 8. The reaction mixture was extracted with ethyl acetate (3 x 500 ml). 9. The organic layers were combined and dried over anhydrous sodium sulfate, followed by concentration in vacuo. 10. Purification was carried out by column chromatography using silica gel saturated with triethylamine (100-200 mesh), with 20% ethyl acetate in hexane as eluent. 11. The target fractions were collected to afford 1-ethyl-1H-pyrazol-5-amine, Yield: 66.0 g (1.0 g). 12. , Yield: 66.0 g (15% yield), mass spectrum (m/z): (M+H)+ 111.98. | [References]
[1] Patent: WO2010/46791, 2010, A1. Location in patent: Page/Page column 30-31 |
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