| Identification | More | [Name]
4-(2-Aminoethyl)benzenesulfonamide | [CAS]
35303-76-5 | [Synonyms]
4-(2-AMINOETHYL)BENZENESULFONAMIDE
4-(2-AMINOETHYL)BENZENE SULFONMIDE
4-(2-AMINOETHYL)BENZENE SULPHONAMIDE
LABOTEST-BB LT00080735
OTAVA-BB BB7020410047
P-(2-AMINOETHYL)BENZENESULFONAMIDE
TIMTEC-BB SBB003544
4-(2-Ethylamino) Benzene Sulfonamide
4-Aminoethylbenzenesulfonamide
Benzenesulfonamide, 4-(2-aminoethyl)-(9CI)
4-(2-Aminoethyl)benzesulfonamide
4-(2-aminoethyl)benzenesulfonamide (intermediate of glibenclamide,glipizide,gliquidone)
Benzenesulfonamide, 4-(2-aminoethyl)- | [EINECS(EC#)]
252-501-0 | [Molecular Formula]
C8H12N2O2S | [MDL Number]
MFCD00010301 | [Molecular Weight]
200.26 | [MOL File]
35303-76-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white to yellowish crystalline powder | [Melting point ]
150-152 °C (lit.) | [Boiling point ]
387.4±44.0 °C(Predicted) | [density ]
1.2581 (rough estimate) | [vapor pressure ]
0Pa at 25℃ | [refractive index ]
1.5690 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
10.16±0.10(Predicted) | [color ]
White | [Water Solubility ]
15.5g/L at 20℃ | [InChI]
InChI=1S/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12) | [InChIKey]
FXNSVEQMUYPYJS-UHFFFAOYSA-N | [SMILES]
C1(S(N)(=O)=O)=CC=C(CCN)C=C1 | [LogP]
-3.1 at 19.8℃ | [CAS DataBase Reference]
35303-76-5(CAS DataBase Reference) |
| Questions And Answer | Back Directory | [Uses]
4-(2-Aminoethyl)benzenesulfonamide is used as the starting material in the synthesis of Des(5-methylpyrazinecarbonyl) trans-4-Methyl Glipizide (D292605); a degradation product of Glimepiride (G410150) which is a sulfonylurea hypoglycemic agent and an antidiabetic. 4-(2-Aminoethyl)benzenesulfonamide is also used as a reagent in the synthesis of deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi,Xn | [Risk Statements ]
R34:Causes burns.
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN3259 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29350090 |
| Hazard Information | Back Directory | [Chemical Properties]
white to yellowish crystalline powder | [General Description]
The human hepatocellular carcinoma (HCC) cells were treated with its inhibitor 4-(2-aminoethyl)benzenesulfonamide. | [Flammability and Explosibility]
Notclassified |
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