| Identification | Back Directory | [Name]
1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE | [CAS]
35454-39-8 | [Synonyms]
1-METHYL-4-IMIDAZOLE ACETIC ACID HCL
1-Methyl-15N2-imidazol-4-yl acetic acid HCl
2-(1-METHYL-1H-IMIDAZOL-4-YL)ACETIC ACID HCL
1-MethyliMidazole-4-acetic acid hydrochloride
1-METHYL-4-IMIDAZOLEACETIC ACID HYDROCHLORIDE
MECHAN. MEASURING STATION, AMELUNG*NO. D10013
1-METHYL-4-IMIDAZOLEACETIC ACID HYDROGEN CHLORIDE
1-methyl-1H-imidazol-4-acetic acid monohydrochloride
(1-Methyl-1H-imidazol-4-yl)-acetic acid hydrochloride
2-(1-Methyl-1H-imidazol-4-yl)acetic acid hydrochloride
2-(1-Methyl-1H-imidazol-4-yl)ethanoic acid hydrochloride
1H-Imidazole-4-aceticacid, 1-methyl-, hydrochloride (1:1) | [EINECS(EC#)]
252-577-5 | [Molecular Formula]
C6H9ClN2O2 | [MDL Number]
MFCD00036998 | [MOL File]
35454-39-8.mol | [Molecular Weight]
176.6 |
| Chemical Properties | Back Directory | [Melting point ]
204-206℃ | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Light Beige to Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Description]
1-Methyl-4-imidazoleacetic acid (MIMA) is a stable metabolite of histamine that is produced by the oxidation of the primary metabolite, N-methylhistamine. Urinary levels of MIMA are commonly measured to evaluate histamine secretion, particularly in the context of systemic mastocytosis. | [Uses]
1-Methyl-4-imidazoleacetic Acid Hydrochloride is a metabolite of histamine (H436500), which is produced by mast cells and involved with the inflammatory response. 1-Methyl-4-imidazoleacetic Acid Hydrochloride can also be used to synthesize N-[1-(9,10-methano-9-anthracenylmethyl)-4-piperidinyl]alkanamides and analogs as dopamine D2 receptor antagonists. | [References]
[1] KERR J W. IDENTIFICATION OF HISTAMINE METABOLITE 1-METHYL, 4-IMIDAZOLE ACETIC ACID IN HUMAN URINE AND ITS ABSENCE IN STATUS ASTHMATICUS.[J]. BMJ?: British Medical Journal, 1964, 2 5409: 606-608. DOI: 10.1136/bmj.2.5409.606
[2] J. J. VAN DOORMAAL. Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions[J]. Allergy, 2012, 67 5: 683-690. DOI: 10.1111/j.1398-9995.2012.02809.x
[3] BYRTHE J.P.R. VOS BSC Pieter C van V V M Eveline van der Veer PhD, PHD André B M M, PHD , et al. Diminished reliability of tryptase as risk indicator of mastocytosis in older overweight subjects[J]. Journal of Allergy and Clinical Immunology, 2015, 135 3: Pages 792-798. DOI: 10.1016/j.jaci.2014.05.047
[4] A. TSOLAKIS. Histidine decarboxylase and urinary methylimidazoleacetic acid in gastric neuroendocrine cells and tumours.[C]//21 47 1. 2015: 13240-13249. DOI: 10.3748/wjg.v21.i47.13240 |
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