| Identification | Back Directory | [Name]
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide | [CAS]
354812-16-1 | [Synonyms]
AA43279, CID 4278270
3-amino-5-(4-methoxyphenyl)-2-Thiophenecarboxamide
2-Thiophenecarboxamide, 3-amino-5-(4-methoxyphenyl)-
3-Amino-5-(4-Methoxyphenyl)-2-Thiophenecarboxamide(WXC03635) | [Molecular Formula]
C12H12N2O2S | [MDL Number]
MFCD00277422 | [MOL File]
354812-16-1.mol | [Molecular Weight]
248.3 |
| Chemical Properties | Back Directory | [Boiling point ]
456.7±45.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in DMSO (up to 35 mg/ml) | [form ]
solid | [pka]
15.71±0.50(Predicted) | [color ]
Tan | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Description]
AA43279 (354812-16-1) is a selective Nav1.1 activator. In HEK-293 cells expressing human Nav1.1 channels AA43279 increased the Nav1.1-mediated current in a concentration dependent manner (EC50=9.5 μM). In rat hippocampal brain slices it increased the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increased the spontaneous inhibitory post-synaptic currents recorded from pyramidal neurons. It displayed anticonvulsant activity in vivo. Important tool compound for exploring the physiology of Nav1.1 channels.1 | [Uses]
AA43279 is an in gamma-aminobutyric acid (GABA) fast-firing interneurons located activator for Nav1.1 channel (SCN1A) with an EC50 of 9.5 μM. AA43279 enhances specific neuronal firing activity in vitro, and exhibits anticonvulsant activity in rat MEST model[1]. | [IC 50]
Nav1.1: 9.5 μM (IC50); Nav1.6: 11.6 μM (IC50); Nav1.5: 14.4 μM (IC50); Nav1.2: 22.8 μM (IC50) | [References]
1) Frederiksen et al. (2017), A small molecule activator of Nav 1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo.; Eur. J. Neuroscience, 46 1887 |
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