| Identification | Back Directory | [Name]
Histone Acetyltransferase Inhibitor IV, CPTH2 | [CAS]
357649-93-5 | [Synonyms]
CPTH2
Histone Acetyltransferase Inhibitor IV, CPTH2
Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone
Cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone | [Molecular Formula]
C14H14ClN3S | [MDL Number]
MFCD02307488 | [MOL File]
357649-93-5.mol | [Molecular Weight]
291.8 |
| Chemical Properties | Back Directory | [Melting point ]
190-191 °C | [Boiling point ]
460.3±37.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
14.57±0.20(Predicted) | [color ]
white to beige | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) | [Sensitive ]
Light Sensitive | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. | [InChI]
InChI=1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18) | [InChIKey]
YYTHPXHGWSAKIZ-UHFFFAOYSA-N | [SMILES]
C1(=N/NC2=NC(C3=CC=C(Cl)C=C3)=CS2)/CCCC/1 |
| Hazard Information | Back Directory | [Description]
CPTH2 (357649-93-5) is a selective inhibitor of the histone acetyltransferase Gcn5P both?in vitro?and?in vivo?(IC50?= 0.8 mM).?In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3. It’s?in vivo?activity may involve more histonic and/or non-histonic Gcn5p substrates. | [Uses]
CPTH2 is a histone acetyltransferase inhibitor that modulates Gcn5p dependent functional network in vitro and in vivo. | [Definition]
ChEBI: Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl]hydrazone is a member of the class of 1,3-thiazole bearing 2-cyclopentylidenehydrazino and 4-chlorophenyl substituents at positions 2 and 4 respectively. It has a role as an EC 2.3.1.48 (histone acetyltransferase) inhibitor. It is a member of 1,3-thiazoles, a hydrazone and a member of monochlorobenzenes. | [General Description]
CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines. | [Biochem/physiol Actions]
CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents. | [Synthesis]
General procedure for the synthesis of 4-(4-chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole from 2-cyclopentylidenehydrazine-1-carbothioamide and α-bromo-4-chloroacetophenone: Accurately weighed 0.157 g of cyclopentanone condensed thiosemicarbazone Schiff base and 0.234 g of p-chloro-α-bromoacetophenone were placed in a reaction vial, and 15 mL of isopropanol was added as solvent. The reaction mixture was stirred at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of ethyl acetate: petroleum ether = 1:2). After 4 hours of reaction, no significant change in the reaction system was observed and the reaction was terminated. The reaction mixture was filtered and the resulting filter cake was washed with ethanol to yield 0.271 g of white solid product. | [storage]
4°C, protect from light | [References]
1) Chimenti?et al. (2009),?A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone); J. Med .Chem.,?52?530 |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
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| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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