| Identification | Back Directory | [Name]
Dexamethasone-d5 | [CAS]
358731-91-6 | [Synonyms]
Corson-d5
Decalix-d5
Decasone-d5
Dekacort-d5
Decacort-d5
DecaderM-d5
Decadron-d5
CortisuMMan-d5
Aeroseb-Dex-d5
Dexamethasone-d5
[2H5]-Dexamethasone
Dexamethasone-4?6α?21?21-[d4]
16α-Methyl-9α-fluoroprednisolone-d5
(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-pregna-1,4-diene-3,20-dione-d5 | [Molecular Formula]
C22H29FO5 | [MOL File]
358731-91-6.mol | [Molecular Weight]
392.461 |
| Chemical Properties | Back Directory | [Melting point ]
230-232°C | [storage temp. ]
-20°C Freezer | [solubility ]
Dioxane (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated) | [form ]
Solid | [color ]
Off-White to Pale Yellow |
| Hazard Information | Back Directory | [Chemical Properties]
White to Off-White Solid | [Uses]
A glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase. | [storage]
Store at -20°C | [References]
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] LaLone CA, et al. Effects of a glucocorticoid receptor agonist, Dexamethasone, on fathead minnow reproduction, growth, and development. Environ Toxicol Chem. 2012 Mar;31(3):611-22. DOI:10.1002/etc.1729
[3] Adcock IM, et al. Ligand-induced differentiation of glucocorticoid receptor (GR) trans-repression and transactivation: preferential targetting of NF-kappaB and lack of I-kappaB involvement. Br J Pharmacol. 1999 Jun;127(4):1003-11 DOI:10.1038/sj.bjp.0702613
[4] Rocksén D, et al. Differential anti-inflammatory and anti-oxidative effects of Dexamethasone and N-acetylcysteine in endotoxin-induced lung inflammation. Clin Exp Immunol. 2000 Nov;122(2):249-56 DOI:10.1046/j.1365-2249.2000.01373.x
[5] Roussel D, et al. Dexamethasone treatment specifically increases the basal proton conductance of rat liver mitochondria. FEBS Lett. 2003 Apr 24;541(1-3):75-9. DOI:10.1016/s0014-5793(03)00307-7
[6] Ballabh P, et al. Neutrophil and monocyte adhesion molecules in bronchopulmonary dysplasia, and effects of corticosteroids. Arch Dis Child Fetal Neonatal Ed. 2004 Jan;89(1):F76-83. DOI:10.1136/fn.89.1.f76
[7] Heidi Ledford. et al. Coronavirus Breakthrough: Dexamethasone Is First Drug Shown to Save Lives. Nature. 2020 Jun 16. DOI:10.1038/d41586-020-01824-5
[8] Yun Chen, et al. Glucocorticoids inhibit production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses. Int J Clin Exp Pathol 2018;11(7):3391-3397. |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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