| Identification | Back Directory | [Name]
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate | [CAS]
359595-95-2 | [Synonyms]
Methyl 4-[8-[[(3,4-dimethylphenyl)amino]sulfonyl]-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl]benzoate | [Molecular Formula]
C28H28N2O4S | [MOL File]
359595-95-2.mol | [Molecular Weight]
488.6 |
| Chemical Properties | Back Directory | [Boiling point ]
653.4±65.0 °C(Predicted) | [density ]
1.273±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
9.64±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
MDM2/XIAP-IN-1 (compound 14) is an orally active inhibitor of dual MDM2/XIAP. MDM2/XIAP-IN-1 has anti-cancer activity with an IC50 value of 0.3 μM, which can be used in cance rescrch[1]. | [in vivo]
MDM2/XIAP-IN-1 Pharmacokinetic Analysis in Male SD rats Model[1]
| Route | Dose (mg/kg) | AUClast (ng·h/mL) | t1/2 (h) | Clobs (L·h/kg) | F (%) | | i.v. | 10 | 4750 | 0.94 | 2.12 | / | | p.o. | 25 | 0.71 | / | / | 5.9% |
| [References]
[1] Zhongzhi Wu, et al. Discovery of N-(3,4-Dimethylphenyl)-4-(4-isobutyrylphenyl)-2,3,3a,4,5,9b-hexahydrofuro[3,2-c]quinoline-8-sulfonamide as a Potent Dual MDM2/XIAP Inhibitor. Med. Chem. 2021, 64, 4. |
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