| Identification | Back Directory | [Name]
4BP-TQS | [CAS]
360791-49-7 | [Synonyms]
4BP-TQS
4BP-TQS >=98% (HPLC)
3H-Cyclopenta[c]quinoline-8-sulfonamide, 4-(4-bromophenyl)-3a,4,5,9b-tetrahydro- | [Molecular Formula]
C18H17BrN2O2S | [MOL File]
360791-49-7.mol | [Molecular Weight]
405.31 |
| Chemical Properties | Back Directory | [Melting point ]
>202°C (dec.) | [Boiling point ]
566.2±60.0 °C(Predicted) | [density ]
1.505±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
powder | [pka]
10.21±0.40(Predicted) | [color ]
white to beige | [InChI]
1S/C18H17BrN2O2S/c19-12-6-4-11(5-7-12)18-15-3-1-2-14(15)16-10-13(24(20,22)23)8-9-17(16)21-18/h1-2,4-10,14-15,18,21H,3H2,(H2,20,22,23) | [InChIKey]
YNCXHXYZTLIZTO-UHFFFAOYSA-N | [SMILES]
BrC1=CC=C(C2C(CC=C3)C3C(C=C(S(N)(=O)=O)C=C4)=C4N2)C=C1 |
| Hazard Information | Back Directory | [Uses]
4BP-TQS is an agonist of human α7 nicotinic acetylcholine receptor (a7-nAChR), activates the channel via binding to an allosteric transmembrane site. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone. | [Biochem/physiol Actions]
4BP-TQS is an atypical agonist of a7-nAChR that binds to the receptor in an intrasubunit cavity, and activates the channel via a mechanism that is distinct from conventional agonists. Maximal activation of a7-nAChR by 4BP-TQS is eight fold greater than activation by a maximum dose of acetylcholine (Ach), and 4BP-TQS can poteniate an EC10 concentration of ACh to invoke a response that is 540-fold higher than the maximal dose of ACh alone. |
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