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36085-73-1

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36085-73-1 Structure

36085-73-1 Structure
IdentificationBack Directory
[Name]

B-HT 920 DIHYDROCHLORIDE
[CAS]

36085-73-1
[Synonyms]

b-ht920
4H-Thiazolo[4
B-HT 920 2HCl
5-d]azepin-2-aMine
hydrochloride (1:2)
Hydrochloric talipexole
B-HT 920 (hydrochloride)
B-HT 920 DIHYDROCHLORIDE
talipexole hydrochloride
talipexoledihydrochloride
TALIPEXOLE DIDHYDROCHLORIDE
8-tetrahydro-6-(2-propen-1-yl)-
B-HT920dihydrochlorideTalipexole
Talipexole dihydrochloride(B-HT 920)
B-HT 920 DIHYDROCHLORIDE A2 ADRENOCEPTOR AGONI
2-amino-6-allyl-4,5,7,8-tetrahydro-6h-thiazolo(5,4-d)azepin-dihydrochlorid
5-d)azepin-2-amine,5,6,7,8-tetrahydro-6-(2-propenyl)-4h-thiazolo(dihydroch
6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride
5,6,7,8-tetrahydro-6-(2-propenyl)-4h-thiazolo(4,5-d)azepin-2-aminedihydrochl
6-ALLYL-2-AMINO-5,6,7,8-TETRAHYDRO-4H-THIAZOLO[4,5-D]AZEPINE DIHYDROCHLORIDE
5,6,7,8-TETRAHYDRO-6-(2-PROPENYL)-4H-THIAZOLO[4,5-D]AZEPIN-2-AMINE DIHYDROCHLORIDE
5,6,7,8-TETRAHYDRO-6-(2-PROPENYL)-4H-THIAZOLO[4,5-D]AZEPINE-2-AMINE DIHYDROCHLORIDE
2-Amino-6-allyl-4,5,7,8-tetrahydro-6H-thiazolo(5,4-D)azepin-dihydrochlorid [german]
4H-Thiazolo(4,5-D)azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propenyl)-, dihydrochloride
5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d] azepin-2-amine dihydrochloride
Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride
5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amineDihydrochloride,6-Allyl-2-amino-5,6,7,8-tetrahydro-4
5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine Dihydrochloride, 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine Dihydrochloride
[Molecular Formula]

C10H17Cl2N3S
[MDL Number]

MFCD00274573
[MOL File]

36085-73-1.mol
[Molecular Weight]

282.23
Chemical PropertiesBack Directory
[Appearance]

Light Yellow Solid
[Melting point ]

245°C dec.
[storage temp. ]

Desiccate at RT
[solubility ]

H2O: >20 mg/mL
[form ]

solid
[color ]

off-white
Hazard InformationBack Directory
[Chemical Properties]

Light Yellow Solid
[Uses]

An alpha 2-Adrenoceptor and dopamine D2-receptor agonist. Used as an antiparkinson reagent
[Biological Activity]

Dopamine D 2 receptor agonist, α 2 -adrenoceptor agonist and 5-HT 3 receptor antagonist. Displays antiParkinsonian activity.
[Description]

B-HT 920 is a potent agonist of dopamine 2 (D2) receptors (Ki = 5.8 nM) that shows selectivity for D2 over D3 and D4 receptors. It has neuroprotective and regenerative effects in animal models of Parkinson’s disease. B-HT 920 is also an agonist of α2-adrenergic receptors and an antagonist of serotonin-3 (5-HT3; Ki = 0.35 μM) receptors.
[Definition]

ChEBI: Talipexole dihydrochloride is an azepine.
[References]

[1] FRANCIS K. MAINA  Tiffany A M. Functional Fast Scan Cyclic Voltammetry Assay to Characterize Dopamine D2 and D3 Autoreceptors in the Mouse Striatum[J]. ACS Chemical Neuroscience, 2010, 1 6: 450-462. DOI: 10.1021/cn100003u
[2] RICHARD E. MEWSHAW. New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D2 Agonist Pharmacophore. Structure?Activity Relationships of a Series of 2-(Aminomethyl)chromans[J]. Journal of Medicinal Chemistry, 1997, 40 26: 4235-4256. DOI: 10.1021/jm9703653
[3] G S ROBERTSON. In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release.[J]. Journal of Pharmacology and Experimental Therapeutics, 1993, 264 3: 1344-1351.
[4] KITAMURA Y. [Dopaminergic neuroprotection and reconstruction of neural network tiara].[J]. Yakugaku zasshi?: Journal of the Pharmaceutical Society of Japan, 2010, 130 10: 1263-1272. DOI: 10.1248/yakushi.130.1263
[5] HIROAKI NISHIO . 5-HT3 receptor blocking properties of the antiparkinsonian agent, talipexole[J]. General Pharmacology-the Vascular System, 1996, 27 5: Pages 779-785. DOI: 10.1016/0306-3623(95)02125-6
[6] DANIEL RICCI  Carlos A T. Adrenoceptor Involvement in the Cardiovascular Responses to B-HT 920 in Sinoaortic Denervated Rats[J]. General Pharmacology-the Vascular System, 1999, 32 1: Pages 29-34. DOI: 10.1016/s0306-3623(98)00018-4
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

3
[RTECS ]

XJ7050340
Spectrum DetailBack Directory
[Spectrum Detail]

B-HT 920 DIHYDROCHLORIDE(36085-73-1)1HNMR
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