| Identification | More | [Name]
3-Acetyl-2,5-dichlorothiophene | [CAS]
36157-40-1 | [Synonyms]
1-(2,5-DICHLORO-3-THIENYL)-1-ETHANONE
1-(2,5-DICHLORO-3-THIENYL)ETHAN-1-ONE
2,5-DICHLORO-3-THIENYL METHYL KETONE
3-ACETYL-2,5-DICHLOROTHIOPHENE
AKOS 1010
1-(2,5-Dichloro-3-thienyl)ethanone
1-(2,5-Dichloro-thiophen-3-yl)-ethanone
Ethanone, 1-(2,5-dichloro-3-thienyl)-
1-(2,5-Dichlorothien-3-yl)ethan-1-one
2,5-Dichloro-3-acetylthiophene
Lightyellowcrystallinepowder
3-ACETYL-2,5-DICHLOROTHIOPHENE,98+% | [EINECS(EC#)]
252-893-3 | [Molecular Formula]
C6H4Cl2OS | [MDL Number]
MFCD00014522 | [Molecular Weight]
195.07 | [MOL File]
36157-40-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
3-Acetyl-2,5-dichlorothiophene may be used in the following syntheses:
- substituted chalcones
- AL-4623A and AL-4862 (brinzolamide), inhibitors of topical carbonic anhydrase
- 2,5-dichlorothiophene-3-carboxylic acid, which is the starting reagent required for the synthesis of 2,5-dichloro-N-(substituted amino-carbonothioyl)thiophene-3-carboxamides and 2-(substituted amino)-4H-thieno[3,2-e]-1,3-thiazin-4-ones
| [Definition]
ChEBI: 1-(2,5-Dichloro-3-thienyl)ethan-1-one is an aromatic ketone. | [Synthesis]
1-Methyl-4-chlorobutenal was reacted with a strong base to remove the active hydrogen at the α-position, then docked with thioacetyl chloride and reacted at 60-80 degrees Celsius to obtain the target product 3-acetyl-2,5-dichlorothiophene. |
|
|