| Identification | Back Directory | [Name]
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE | [CAS]
36341-25-0 | [Synonyms]
Y109
Y-109
YL-109
Y-109;Y109
Phenol, 4-(2-benzothiazolyl)-2-methoxy-
4-(benzo[d]thiazol-2-yl)-2-Methoxyphenol
4-(1,3-Benzothiazol-2-yl)-2-methoxyphenol
2-(4-HYDROXY-3-METHOXYPHENYL)BENZOTHIAZOLE
4-(3H-1,3-benzothiazol-2-ylidene)-2-methoxycyclohexa-2,5-dien-1-one | [Molecular Formula]
C14H11NO2S | [MDL Number]
MFCD00030231 | [MOL File]
36341-25-0.mol | [Molecular Weight]
257.31 |
| Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Biological Activity]
YL-109 is a novel antitumor agent that inhibits the growth and invasion of breast cancer cells in vitro and in vivo. | [in vitro]
YL-109 (0.001-10 μM; 96 h or 24 h) inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
YL-109 (1 μM) increases both CHIP mRNA and protein levels in MDA-MB-231 cells. Cell Proliferation Assay | Cell Line: | < td class="col2"> MCF-7 and MDA-MB-231 cells | Concentration: | 0.001, 0.01, 0.1, 1, 10 μM | | Incubation Time: | 96 hours | | Result: | Strongly inhibited cell proliferation of MCF-7 and MDA-MB-231 cells in a dose-dependent manner (IC 50 =85.8 nM and 4.02 μM, respectively). | | [in vivo]
YL-109 (15 mg/kg; sc for every 2 d) inhibits both tumor growth and cancer metastasis of breast cancer cells in vivo. < /p> | Animal Model: | BALB/cAjcl-nu/nu female mice (4-5 weeks) inoculated with MCF-7 or MDA-MB-231 cells | | Dosage: | 15 mg/kg | | Administration: < /td> | Sc every 2 days for 63 days | | Result: | Suppressed tumor growth in mice injected with MCF-7 and MDA-MB-231 cells. | |
|
|