ChemicalBook--->CAS DataBase List--->1370003-76-1

1370003-76-1

1370003-76-1 Structure

1370003-76-1 Structure
IdentificationBack Directory
[Name]

yk11
[CAS]

1370003-76-1
[Synonyms]

yk1
YK-11-OA
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YK-11 (Mixture of diasteromers)
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High quality 1370003-76-1 Sarms YK11 CAS NO.1370003-76-1 Manufacturers wholesale
(17α,20E)-17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-Norpregna-4,20-diene-21-carboxylic acid, methyl ester
(17alpha,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester
19-Norpregna-4,20-diene-21-carboxylic acid, 17,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-, methyl ester, (17α,20E)-
[EINECS(EC#)]

1532714-185-1
[Molecular Formula]

C25H34O6
[MDL Number]

MFCD30343804
[MOL File]

1370003-76-1.mol
[Molecular Weight]

430.53
Chemical PropertiesBack Directory
[Melting point ]

134-137°C
[Boiling point ]

564.4±50.0 °C(Predicted)
[density ]

1.22±0.1 g/cm3(Predicted)
[storage temp. ]

-20°C Freezer
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[color ]

White to Pale Yellow
[InChIKey]

KCQHQCDHFVGNMK-PQUNLUOYSA-N
Safety DataBack Directory
[Symbol(GHS) ]


GHS05,GHS08
[Signal word ]

Danger
[Hazard statements ]

H315-H318-H334-H317-H341-H361-H370-H413
[Precautionary statements ]

P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501
Hazard InformationBack Directory
[Description]

YK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.
[Uses]

YK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.
[Mechanism of action]

YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.
[References]

[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231
Spectrum DetailBack Directory
[Spectrum Detail]

yk11(1370003-76-1)1HNMR
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