| Identification | More | [Name]
4-Fluoro-3-nitroaniline | [CAS]
364-76-1 | [Synonyms]
3-NITRO-4-FLUOROANILINE
4-FLUORO-3-NITROANILINE
4-fluoro-3-nitro-benzamine
4-FLUORO-3-NITRO-PHENYLAMINE
5-AMINO-2-FLUORONITROBENZENE
4-F-3NA
4-fluoro-3-nitro-anilin
4-fluoro-3-nitro-benzenamin
4-Fluoro-3-nitrobenzenamine
Aniline, 4-fluoro-3-nitro-
Benzenamine, 4-fluoro-3-nitro-
4-Fluoro-3-nitroaniline98%
4-Fluor-3-nitroanilin
4-Fluoro-3-phenylnitramine
4-FLUORO-3-NITROANILINE ( DRY ) | [EINECS(EC#)]
206-665-5 | [Molecular Formula]
C6H5FN2O2 | [MDL Number]
MFCD00007833 | [Molecular Weight]
156.11 | [MOL File]
364-76-1.mol |
| Chemical Properties | Back Directory | [Appearance]
whitetolightyellowcrystalpowde | [Melting point ]
94-96 °C (lit.) | [Boiling point ]
331.3±22.0 °C(Predicted) | [density ]
0.43 g/cm3 (20℃) | [Fp ]
196 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Powder | [pka]
2.36±0.10(Predicted) | [color ]
Ochre | [Water Solubility ]
Insoluble | [BRN ]
2210199 | [InChI]
InChI=1S/C6H5FN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2 | [InChIKey]
LLIOADBCFIXIEU-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(F)C([N+]([O-])=O)=C1 | [CAS DataBase Reference]
364-76-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 4-fluoro-3-nitro-(364-76-1) | [EPA Substance Registry System]
364-76-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 1325 4.1/PG 2
| [WGK Germany ]
2
| [RTECS ]
BY1700000
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29214210 |
| Hazard Information | Back Directory | [Chemical Properties]
whitetolightyellowcrystalpowde | [Uses]
4-Fluoro-3-nitroaniline was used in the preparation of commercial hair dyes. | [Uses]
4-Fluoro-3-nitroaniline is used in the preparation of commercial hair dyes. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. | [Definition]
ChEBI:4-fluoro-3-nitroaniline is a nitroaniline and an organofluorine compound. | [Synthesis]
Example 43: General procedure for the synthesis of 4-fluoro-3-nitroaniline and 2-fluoro-5-nitroaniline from 2,4-dinitrofluorobenzene. A hydrogenation reaction was carried out according to the method described in Example 25 using 5% rhodium/alumina as a catalyst. This was done as follows: 18.61 g (0.10 mol) of 2,4-dinitrofluorobenzene was dissolved in a solvent mixture of 100 ml of glacial acetic acid and 100 ml of anhydrous ethanol in the presence of an alumina hydrogenation catalyst containing 0.50 g of rhodium. The hydrogen pressure was maintained at 370 psi during the reaction and the reaction time was 2 hours. Upon completion of the reaction, the product was separated by column chromatography to afford 2.79 g of 2-fluoro-5-nitroaniline in 17.6% yield. In addition, 0.85 g of 4-fluoro-3-nitroaniline was recovered as a second fraction. | [References]
[1] Tetrahedron Letters, 1990, vol. 31, # 43, p. 6141 - 6144
[2] Tetrahedron Letters, 1990, vol. 31, # 43, p. 6141 - 6144
[3] Patent: US5105012, 1992, A
[4] Recueil des Travaux Chimiques des Pays-Bas, 1946, vol. 65, p. 329,330
[5] Russian Journal of General Chemistry, 2006, vol. 76, # 1, p. 76 - 81 |
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