| Identification | Back Directory | [Name]
cycloheterophyllin | [CAS]
36545-53-6 | [Synonyms]
cycloheterophyllin
(+)-2,3,8-Trihydroxy-11,11-dimethyl-13-(3-methyl-2-butenyl)-6-(2-methyl-1-propenyl)-6H,7H,11H-bis[1]benzopyrano[4,3-b:6',7'-e]pyran-7-one
6H,7H,11H-Bis[1]benzopyrano[4,3-b:6',7'-e]pyran-7-one, 2,3,8-trihydroxy-11,11-dimethyl-13-(3-methyl-2-buten-1-yl)-6-(2-methyl-1-propen-1-yl)-, (+)- | [Molecular Formula]
C30H30O7 | [MOL File]
36545-53-6.mol | [Molecular Weight]
502.55 |
| Hazard Information | Back Directory | [Description]
Cycloheterophyllin exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA).
Cycloheterophyllin has an antioxidant effect and can effectively scavenge free radicals.
3. Cycloheterophyllin is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.
4. Cycloheterophyllin shows strong inhibition of arachidonic acid (AA)-induced platelet aggregation, due to an inhibitory effect on cyclooxygenase. | [Uses]
Cycloheterophyllin is a flavonoid, that can be isolated from Artocarpus communis and A. heterophyllus. Cycloheterophyllin shows antiinflammatory activity[1]. | [Definition]
ChEBI: Cycloheterophyllin is an extended flavonoid. | [target]
PKA | PKC | NADPH-oxidase | NF-kB | Caspase | MAPK | [References]
[1] Wei BL, et al. Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis. J Agric Food Chem. 2005 May 18;53(10):3867-71. DOI:10.1021/jf047873n |
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