| Identification | Back Directory | [Name]
9-OXO-15S-HYDROXY-PROSTA-5Z,8(12),13E,17Z-TETRAEN-1-OIC ACID | [CAS]
36614-32-1 | [Synonyms]
PGB3
PROSTAGLANDIN B3
DQRGQQAJYRBDRP-UNBCGXALSA-N
9-OXO-15S-HYDROXY-PROSTA-5Z,8(12),13E,17Z-TETRAEN-1-OIC ACID
(5Z,13E,15S,17Z)-15-Hydroxy-9-oxoprosta-5,8(12),13,17-tetraen-1-oic acid
7-[2-[(3S)-3-hydroxyocta-1,5-dienyl]-5-oxocyclopenten-1-yl]hept-5-enoic acid | [Molecular Formula]
C20H28O4 | [MDL Number]
MFCD00797637 | [MOL File]
36614-32-1.mol | [Molecular Weight]
332.43 |
| Chemical Properties | Back Directory | [Boiling point ]
548.8±50.0 °C(Predicted) | [density ]
1.135±0.06 g/cm3(Predicted) | [solubility ]
DMF: >75 mg/ml (from PGB2); DMSO: >50 mg/ml (from PGB2); Ethanol: >100 mg/ml (from PGB2); PBS pH 7.2: >2 mg/ml (from PGB2) | [pka]
4.74±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
Prostaglandin B3 (PGB3) is a non-enzymatic dehydration product resulting from the treatment of Prostaglandin E3 (PGE3) with strong base. In a structure-activity binding study to determine the affinity of various prostaglandins to human PPARγ, PGB3 exhibited a Ki value greater than 1 mM. In contrast, PGB1 and PGB2 showed significantly higher affinity for PPARγ, with Ki values of 26 and 77 μM, respectively, the same assay. | [Uses]
Prostaglandin B3 (PGB3) is a member of the class of prostaglandins B and a secondary alcohol. PGB3 exhibits a rather low affinity to human PPARγ with a Ki value greater than 1 mM compared with Ki values of 26.28 ± 8.7 μM for PGB1 and 77 ± 37.7 μM for PGB2[1]. | [IC 50]
PPARγ | [References]
[1] Ferry G, et al. Binding of prostaglandins to human PPARgamma: tool assessment and new natural ligands. Eur J Pharmacol. 2001 Apr 6;417(1-2):77-89. DOI:10.1016/s0014-2999(01)00907-4 |
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