| Identification | More | [Name]
3-Chloro-4-fluoroaniline | [CAS]
367-21-5 | [Synonyms]
3-CHLORO-4-FLUOROANILINE
3-CHLORO-4-FLUOROBENZENAMINE
3-CHLORO-4-FLUORO-PHENYLAMINE
AKOS BBS-00003577
LABOTEST-BB LTBB000779
3-chloro-4-fluoro-benzenamin
Fluorochloroaniline
4-Fluoro-3-chloroaniline
3-CHLORO-4-FLUOROANILINE OEKANAL, 250 MG
3-Chloro-4-Fluoroaniline99%
3-Chloro-4-fluoroaniline,98%
3-/4-CHLOROFLUOROANILINE
Benzenamine, 3-chloro-4-fluoro-
3-Chloro-4-fluoroaniline 98%
3-Chlor-4-fluoranilin
3-CHLORO-4-FLUOROANILINE A
3-CHLORO-4-FLUOROANILINE B
3-CHLORO-4-FLUOROANILINE, 99.5+%
3-CHLORO-4-FLUOROANILINENORFLOXACIN
3-CHLORO-4-FLUOROANILINE pure | [EINECS(EC#)]
206-682-8 | [Molecular Formula]
C6H5ClFN | [MDL Number]
MFCD00007767 | [Molecular Weight]
145.56 | [MOL File]
367-21-5.mol |
| Chemical Properties | Back Directory | [Appearance]
dark purple to black solid | [Melting point ]
42-44 °C (lit.) | [Boiling point ]
227-228 °C (lit.) | [bulk density]
1000kg/m3 | [density ]
1,226 g/cm3 | [vapor pressure ]
0.01 hPa (20 °C) | [refractive index ]
1,54-1,542 | [Fp ]
>230 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
10g/l | [form ]
Crystalline Solid | [pka]
3.60±0.10(Predicted) | [color ]
Beige to brown | [PH]
7 (10g/l, H2O, 20℃) | [Stability:]
Stable. Incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides, chloroformates. May be air-sensitive. | [Water Solubility ]
10 g/L (20 ºC) | [Detection Methods]
HPLC | [BRN ]
1562786 | [InChIKey]
YSEMCVGMNUUNRK-UHFFFAOYSA-N | [CAS DataBase Reference]
367-21-5(CAS DataBase Reference) | [EPA Substance Registry System]
367-21-5(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi,Xn | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
2
| [F ]
9-23 | [Hazard Note ]
Irritant/Toxic | [TSCA ]
T | [HazardClass ]
6.1 | [HazardClass ]
TOXIC | [PackingGroup ]
III | [HS Code ]
29214210 | [Toxicity]
LD50 orally in Rabbit: 506 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
dark purple to black solid | [Uses]
4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity. | [General Description]
The exposure of workers to 3-chloro-4-fluoroaniline (CFA) was monitored by an HPLC method. | [Synthesis]
In a reaction vessel equipped with a mechanical stirrer and a reflux condenser tube, 0.83 mol of erbium chloride powder, 150 mL of an aqueous sodium bromide solution with a mass fraction of 22%, and 3-amino-3-(4-ethylphenyl)propionic acid with a mass fraction of 37% were added. The stirring speed was adjusted to 190 rpm and the reaction mixture was heated to 70 °C and maintained at this temperature for 130 minutes. Subsequently, 0.31 mol of 3-chloro-4-fluoronitrobenzene was slowly added dropwise for a controlled dropwise time of 110 minutes. After the dropwise addition was completed, the reaction temperature was raised to 85 °C and the reaction was refluxed for 4 hours. Upon completion of the reaction, 130 mL of aqueous potassium bisulfite solution with a mass fraction of 40% was added and then distilled under vacuum at 3.3 kPa to collect the 105-115 °C fraction. The resulting fraction was dissolved in 300 mL of 65% o-xylene solution, decolorized by molecular sieve and recrystallized in 87% mass fraction of 2-thiophene acetonitrile solution to finally obtain 41.49 g of 3-chloro-4-fluoroaniline in 92% yield. | [References]
[1] Catalysis Communications, 2010, vol. 11, # 5, p. 451 - 455
[2] RSC Advances, 2016, vol. 6, # 10, p. 7950 - 7954
[3] ACS Catalysis, 2015, vol. 5, # 8, p. 4814 - 4818
[4] Patent: , 2016, . Location in patent: Paragraph 0023; 0024; 0025
[5] Synthetic Communications, 2002, vol. 32, # 18, p. 2849 - 2853 |
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