| Identification | Back Directory | [Name]
Benzoic acid, 2-hydroxy-5-[2-[4-[(1Z)-3-[4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]-1-piperidinyl]-3-oxo-1-phenyl-1-propen-1-yl]phenyl]diazenyl]-, sodium salt (1:1) | [CAS]
367249-56-7 | [Synonyms]
UR12746
UR-12746
Dersalazine sodium
UR 12746S (sodium salt)
UR-12746S (sodium salt)
Benzoic acid, 2-hydroxy-5-[2-[4-[(1Z)-3-[4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl]-1-piperidinyl]-3-oxo-1-phenyl-1-propen-1-yl]phenyl]diazenyl]-, sodium salt (1:1) | [EINECS(EC#)]
609-285-1 | [Molecular Formula]
C35H33N6NaO4 | [MOL File]
367249-56-7.mol | [Molecular Weight]
624.68 |
| Hazard Information | Back Directory | [Uses]
Dersalazine (sodium) is a platelet-activating factor (PAF) antagonist. Dersalazine (sodium) can exert intestinal anti-inflammatory activity in rodent colitis models by downregulating IL-17 expression[1]. | [IC 50]
IL-17 | [References]
[1] Camuesco D, et al. The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis. Br J Pharmacol. 2012 Feb;165(3):729-40. DOI:10.1111/j.1476-5381.2011.01598.x |
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