| Identification | Back Directory | [Name]
3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OYLGLYCINE AMIDOHYDROLASE | [CAS]
37289-07-9 | [Synonyms]
EC 3.5.1.24
CHOLOYLGLYCINE HYDROLASE
Choloylglycine Hydrolase, from Clostridium perfringens
3α,7α,12α-trihydroxy-5β-cholan-24-oylglycine amidohydrolase
CHOLOYLGLYCINE HYDROLASE FROM CLOSTRIDIUM PERFINGENS (C. WELCHII)
choloylglycine hydrolase from clostridium perfringens (c. welchii)
Native Clostridium perfringens (C. welchii) Choloylglycine Hydrolase
3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OYLGLYCINE AMIDOHYDROLASE
Choloylglycine Hydrolase from Clostridium perfringens (C.?welchii) lyophilized powder, >=100 units/mg protein | [MDL Number]
MFCD00130789 |
| Hazard Information | Back Directory | [Uses]
The enzyme from Sigma has been used in the analysis of bile samples in various studies. | [Biochem/physiol Actions]
The enzyme is an N-terminal nucleophilic (Ntn) hydrolase that catalyzes the hydrolysis of amide bonds, liberates the glycine/taurine moiety from the steroid core and eventually yields unconjugated bile acids. Agents that oxidize thiol groups (e.g., p-mercuribenzoate, iodoacetamide, Hg2+, Cu2+, and Cd2+) have been shown to strongly inhibit bile salt hydrolase (BSH) activity in Clostridium perfringens. |
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