| Identification | Back Directory | [Name]
KISS-1 (68-121) | [CAS]
374683-24-6 | [Synonyms]
METASTIN
KISSPEPTIN-54
KISS-1 (68-121)
METASTIN (HUMAN)
Kisspeptin(human 54 amino acid variant)
MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (68-121) (HUMAN)
Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan)
Kisspeptin-54 (huMan)
Metastin (huMan), Malignant MelanoMa Metastasis-Suppressor KiSS-1 (68-121) (huMan), KiSS-1 (68-121) (huMan)
H-GLY-THR-SER-LEU-SER-PRO-PRO-PRO-GLU-SER-SER-GLY-SER-ARG-GLN-GLN-PRO-GLY-LEU-SER-ALA-PRO-HIS-SER-ARG-GLN-ILE-PRO-ALA-PRO-GLN-GLY-ALA-VAL-LEU-VAL-GLN-ARG-GLU-LYS-ASP-LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 | [Molecular Formula]
C258H401N79O78 | [MDL Number]
MFCD03457467 | [MOL File]
374683-24-6.mol | [Molecular Weight]
5857.43 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in Water | [Sequence]
Gly-Thr-Ser-Leu-Ser-Pro-Pro-Pro-Glu-Ser-Ser-Gly-Ser-Arg-Gln-Gln-Pro-Gly-Leu-Ser-Ala-Pro-His-Ser-Arg-Gln-Ile-Pro-Ala-Pro-Gln-Gly-Ala-Val-Leu-Val-Gln-Arg-Glu-Lys-Asp-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Hazard Information | Back Directory | [Uses]
Kisspeptin-54(human) (Metastin(human)) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54). Kisspeptin-54(human) binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54(human) inhibits tumor metastasis and stimulates the secretion of gonadotropin (LH) and testosterone[1][2][3][4][5][6][7][8]. | [in vivo]
Kisspeptin-54(human) (0.3-100 nmol/kg, i.p., 30 min before trunk blood and anterior pituitaries are collected) dose-dependently shows activation of the anterior pituitary release of LH in post-pubertal male rats[6].
Kisspeptin-54(human) (0.3-30 nmol/kg, i.p.) produces a dose-dependent effect on c-fos mRNA levels in the anterior pituitary in various ages (PND15, PND30, and PND45) male rats[6].
Kisspeptin-54(human) (0.1-30 nmol/kg, i.p., single) increases serum testosterone in mice, with the same potency as for mouse kisspeptins[7].
Kisspeptin-54(human) (6.7 nmol/rat, s.c.) induces the release of gonadotropin via activation of the hypothalamic GnRH neurons in prepubertal female rats[8].
| Animal Model: | Post-pubertal male rats[6] | | Dosage: | 0.3, 1.0, 3.0, 10, 30 and 100 nmol/kg | | Administration: | Intraperitoneal injection (i.p.), 30 min before trunk blood and anterior pituitaries are collected | | Result: | Elevated c-fos gene expression, as well as the plasma concentrations of LH and testosterone.
Showed no overall statistical effect on plasma testosterone.
|
| [storage]
Store at -20°C | [References]
[1] M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145(9):4073-7. DOI:10.1210/en.2004-0431
[2] M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276(37):34631-6. DOI:10.1074/jbc.M104847200
[3] Nakamura Y, et al. Metastin stimulates aldosterone synthesis in human adrenal cells. Reprod Sci. 2007 Dec;14(8):836-45. DOI:10.1177/1933719107307823
[4] Masui T, et al. Metastin and its variant forms suppress migration of pancreatic cancer cells. Biochem Biophys Res Commun. 2004 Feb 27;315(1):85-92. DOI:10.1016/j.bbrc.2004.01.021
[5] Shoji S, et al. Metastin inhibits migration and invasion of renal cell carcinoma with overexpression of metastin receptor. European urology, 2009, 55(2): 441-451.
[6] Bentsen AH, et al. Maturation of kisspeptinergic neurons coincides with puberty onset in male rats. Peptides. 2010 Feb;31(2):275-83. DOI:10.1016/j.peptides.2009.11.017
[7] Mikkelsen JD, et al. Comparison of the effects of peripherally administered kisspeptins. Regul Pept. 2009 Jan 8;152(1-3):95-100. DOI:10.1016/j.regpep.2008.10.001
[8] Matsui H, et al. Peripheral administration of metastin induces marked gonadotropin release and ovulation in the rat. Biochem Biophys Res Commun. 2004 Jul 23;320(2):383-8. DOI:10.1016/j.bbrc.2004.05.185 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
|