| Identification | Back Directory | [Name]
4,6-dichloro-3-nitropyridin-2-aMine | [CAS]
37660-64-3 | [Synonyms]
4,6-dichloro-3-nitropyridin-2-aMine
4,6-Dichloro-3-nitro-2-pyridinamine
2-Pyridinamine, 4,6-dichloro-3-nitro-
2-AMino-4,6-dichloro-3-nitro-pyridine | [Molecular Formula]
C5H3Cl2N3O2 | [MDL Number]
MFCD26383593 | [MOL File]
37660-64-3.mol | [Molecular Weight]
208 |
| Chemical Properties | Back Directory | [Boiling point ]
366.1±37.0 °C(Predicted) | [density ]
1.723±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
-2.71±0.50(Predicted) | [Appearance]
Light yellow to yellow Solid | [InChI]
InChI=1S/C5H3Cl2N3O2/c6-2-1-3(7)9-5(8)4(2)10(11)12/h1H,(H2,8,9) | [InChIKey]
JHRWWIQRZCVYJZ-UHFFFAOYSA-N | [SMILES]
C1(N)=NC(Cl)=CC(Cl)=C1[N+]([O-])=O |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4,6-dichloro-3-nitro-2-pyridinamine from 2-amino-4,6-dichloropyridine: 2-amino-4,6-dichloropyridine (4.48 g, 27.48 mmol) was added in batches to concentrated sulfuric acid (6 mL) and fuming nitric acid (1.2 mL) was added slowly and dropwise at 5 °C. The reaction mixture was stirred continuously for 10 h at 5 °C. After completion of the reaction, the reaction was quenched with ice water and the pH was adjusted to 7 to give 3.55 g of yellow solid 4,6-dichloro-3-nitro-2-pyridinamine washed with methanol (yield: 62.1%). Melting point: 208°C. 1H-NMR (300MHz, CDCl3), δ (ppm): 6.84 (s, 1H), 6.25 (br, 2H). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3395 - 3398
[2] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 102
[3] Patent: WO2018/75937, 2018, A1. Location in patent: Paragraph 00317; 00318; 00588 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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