| Identification | Back Directory | [Name]
(5-BROMO-PYRIDIN-3-YL)-METHANOL | [CAS]
37669-64-0 | [Synonyms]
AURORA KA-3029
5-Bromo-3-pyridinemethanol
3-Bromopyridine-5-methanol
3-Bromo-5-pyridinemethanol
5-Bromopyridine-3-methanol
3-Pyridinemethanol, 5-bromo-
(5-BROMO-3-PYRIDINYL)METHANOL
(3-Bromo-pyridin-5-yl)methanol
5-Bromo-3-pyridinemethanol >
(5-BROMO-PYRIDIN-3-YL)-METHANOL
3-BROMO-5-HYDROXYMETHYLPYRIDINE
5-Bromo-3-hydroxymethylpyridine
5-BroMo-3-pyridineMethanol, 95+%
(5-BROMO-PYRIDIN-3-YL)-METHANOL ISO 9001：2015 REACH | [Molecular Formula]
C6H6BrNO | [MDL Number]
MFCD03265757 | [MOL File]
37669-64-0.mol | [Molecular Weight]
188.02 |
| Chemical Properties | Back Directory | [Melting point ]
27° | [Boiling point ]
291.5±25.0 °C(Predicted) | [density ]
1.67 | [refractive index ]
1.5940-1.5980 | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Liquid or Low Melting Solid | [pka]
13.29±0.10(Predicted) | [color ]
Clear pale yellow | [InChIKey]
WDVDHJLKXYCOFS-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
5-Bromo-3-pyridinemethanol serves as a precursor for synthesizing [3-(benzyloxy)methyl]-5-bromopyridine via reaction with sodium hydride and benzyl bromide[6]. | [Synthesis]
Sodium borohydride (2.2 g, 59.1 mmol) was added to a suspension of 5-bromo-pyridine-3-carbaldehyde (10.0 g, 53.7 mmol) in MeOH (100 mL) at 0° C. The mixture was stirred at 0° C. for 1 hour before it was quenched by adding water (5.0 mL). Evaporation of solvents afforded a light yellowish oil, which was re-dissolved in EtOAc and washed with water. The organic layer was dried over anhy. Na2SO4, filtered and concentrated in vacuo to give 5-Bromo-3-pyridinemethanol (9.6 g, 95 per cent) as a colourless oil.
| [References]
[1] Patent: WO2013/79452, 2013, A1. Location in patent: Page/Page column 143
[2] Patent: US2013/143863, 2013, A1. Location in patent: Paragraph 1076; 1077; 1078
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 10, p. 4913 - 4925
[4] Patent: US2013/267495, 2013, A1. Location in patent: Paragraph 0454-0455
[5] Patent: US2013/296302, 2013, A1. Location in patent: Paragraph 0549 |
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