| Identification | More | [Name]
5-Bromo-3-pyridinecarboxaldehyde | [CAS]
113118-81-3 | [Synonyms]
3-BROMOPYRIDINE-5-CARBALDEHYDE
3-BROMOPYRIDINE-5-CARBOXALDEHYDE
5-BROMO-3-FORMYLPYRIDINE
5-BROMO-3-PYRIDINECARBOXALDEHYDE
5-BROMONICOTINALDEHYDE
5-BROMO-PYRIDINE-3-CARBALDEHYDE
5-BROMOPYRIDINE-3-CARBOXALDEHYDE
AURORA KA-3030
CHEMBRDG-BB 4011095
5-Bromopyridine-3-carboxaldehyde 97+%
3-Bromo-5-pyridinecarboxaldehyde
5-BROMO-3-FORMYLPYRIDINE 98%
3-BROMO-5-FORMYLPYRIDINE | [EINECS(EC#)]
628-546-0 | [Molecular Formula]
C6H4BrNO | [MDL Number]
MFCD03265758 | [Molecular Weight]
186.01 | [MOL File]
113118-81-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
98-102 °C | [Boiling point ]
251.1±20.0 °C(Predicted) | [density ]
1.683±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Crystalline Powder | [pka]
1.07±0.20(Predicted) | [color ]
White to off-white | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C6H4BrNO/c7-6-1-5(4-9)2-8-3-6/h1-4H | [InChIKey]
NGUVGKAEOFPLDT-UHFFFAOYSA-N | [SMILES]
C1=NC=C(Br)C=C1C=O | [CAS DataBase Reference]
113118-81-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H317-H319 | [Precautionary statements ]
P280-P301+P312+P330-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin .
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2933399990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1 |
| Hazard Information | Back Directory | [Uses]
5-Bromonicotinaldehyde (5-Bromo-3-pyridinecarboxaldehyde) can replace anilines (anilines) compounds and is used in the synthesis of naphthyridines and diazobenzenes[1]. | [Synthesis]
5-Bromo-3-pyridinecarboxaldehyde can be used as a pharmaceutical and chemical synthesis intermediate. In the existing technology, its synthesis method is to use 3,5-dibromo pyridine as raw material and exchange it with butyllithium bromide under ultra-low temperature (-78°C) conditions to prepare 5-Bromo-3-pyridinecarboxaldehyde. Or use 3,5-dibromopyridine as raw material and combine butyllithium and n-butylmagnesium chloride at -15°C to synthesize the product. | [References]
[1] European Journal of Medicinal Chemistry, 2006, vol. 41, # 7, p. 847 - 861
[2] Tetrahedron Letters, 2001, vol. 42, # 29, p. 4841 - 4844
[3] Patent: CN107628990, 2018, A. Location in patent: Paragraph 0020; 0021; 0038; 0039; 0040; 0041; 0042-0046
[4] Patent: US2013/65905, 2013, A1. Location in patent: Paragraph 0189
[5] Patent: WO2004/814, 2003, A1. Location in patent: Page 77 |
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