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[InChI]

InChI=1S/C20H26O3/c1-11-15-12(22-17(11)21)10-14-19(4)8-5-7-18(2,3)13(19)6-9-20(14)16(15)23-20/h10,13-14,16H,5-9H2,1-4H3/t13-,14+,16-,19-,20+/m1/s1
[InChIKey]

OYXDHOVYZKWSRM-PHJMNMFVSA-N
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[in vivo]

Jolkinolide A (40 mg/kg; i.p.; once every 3 days, for 2 months) inhibits the expression of the VEGF protein in A549 cell xenograft tumor model in mouse[1].

Animal Model:Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1]
Dosage:40 mg/kg
Administration:Intraperitoneal injection; once every 3 days for 2 months
Result:Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration.
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