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[in vivo]

Jolkinolide A (40 mg/kg; i.p.; once every 3 days, for 2 months) inhibits the expression of the VEGF protein in A549 cell xenograft tumor model in mouse[1].

Animal Model:Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1]
Dosage:40 mg/kg
Administration:Intraperitoneal injection; once every 3 days for 2 months
Result:Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration.
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