| Identification | Back Directory | [Name]
2-Chloro-6-hydroxynicotinic acid | [CAS]
38025-90-0 | [Synonyms]
2-Chloro-6-hydroxynicotinicaci
2-Chloro-6-Hydroxynicotinic Acid
2-CHLORO-6-HYDROXYNICOTINIC ACID,98%
2-Chloro-6-hydroxynicotinic Acid >
2-Chloro-6-hydroxy-3-pyridinecarboxylic Acid
2-Chloro-6-hydroxypyridine-3-carboxylic acid
2-Chloro-6-hydroxynicotinic acid ISO 9001：2015 REACH
3-Pyridinecarboxylic acid, 2-chloro-1,6-dihydro-6-oxo- | [Molecular Formula]
C6H4ClNO3 | [MDL Number]
MFCD09757508 | [MOL File]
38025-90-0.mol | [Molecular Weight]
173.55 |
| Chemical Properties | Back Directory | [Melting point ]
302°C(lit.) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
powder to crystal | [color ]
White to Light yellow to Light red | [InChI]
InChI=1S/C6H4ClNO3/c7-5-3(6(10)11)1-2-4(9)8-5/h1-2H,(H,8,9)(H,10,11) | [InChIKey]
BSCFFOOWFVZSSK-UHFFFAOYSA-N | [SMILES]
C1(Cl)NC(=O)C=CC=1C(O)=O | [CAS DataBase Reference]
38025-90-0 |
| Questions And Answer | Back Directory | [Uses]
2-Chloro-6-hydroxynicotinic acid, as a pharmaceutical intermediate, can be used to prepare N-(2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)cyclopropanesulfonamide, which is a MEK inhibitor. |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white powder | [Synthesis]
The general procedure for the synthesis of 2-chloro-6-hydroxynicotinic acid from 2,6-dichloronicotinic acid is as follows:
1. 2,6-dichloronicotinic acid (25 g, 130 mmol) and NaOH solution (325 mL, 2N) were added to a 500 mL round bottom flask.
2. The reaction mixture was refluxed at 129°C for 4 hours.
3. Upon completion of the reaction, the mixture was cooled to 0°C.
4. The reaction mixture was acidified to room temperature with 6N aqueous HCl solution.
5. The resulting precipitate was collected by filtration.
6. The precipitate was dried under reduced pressure to give 2-chloro-6-hydroxynicotinic acid (19.87 g, 88% yield). | [References]
[1] Patent: WO2010/108652, 2010, A1. Location in patent: Page/Page column 97
[2] Patent: WO2008/125820, 2008, A1. Location in patent: Page/Page column 33
[3] Patent: CN108314645, 2018, A. Location in patent: Paragraph 0094; 0095; 0096; 0097 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
|