| Identification | More | [Name]
Adrenosterone | [CAS]
382-45-6 | [Synonyms]
11-KETOANDROSTENEDIONE
4-ANDROSTEN-3,11,17-TRIONE
4-ANDROSTENE-3,11,17-TRIONE
ADRENOSTERONE
ANDROST-4-ENE-3,11,17-TRIONE
REICHSTEIN'S ''G''
REICHSTEIN'S 'G'
REICHSTEIN'S SUBSTANCE G
REICHSTEIN'S SUBSTANCE 'G'
11-Oxy-4-androstenedione
Adrenosterone
Androst-4-ene-3,11,17-trione
Reichstein's substance G
11-Ketoandrostenedione, 4-Androstene-3,11,17-trione, Androst-4-ene-3,11,17-trione, Reichsteins substance G
(8β,9α,10β,14α,13β)-Androsta-4-ene-3,11,17-trione
Andrenosterone | [EINECS(EC#)]
206-843-2 | [Molecular Formula]
C19H24O3 | [MDL Number]
MFCD00003606 | [Molecular Weight]
300.39 | [MOL File]
382-45-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
219-222 °C(lit.)
| [alpha ]
300 º (c=1 in chloroform) | [Boiling point ]
381.62°C (rough estimate) | [density ]
1.1381 (rough estimate) | [refractive index ]
290 ° (C=0.2, EtOH) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Optical Rotation]
[α]20/D +300°, c = 1 in chloroform | [Water Solubility ]
98.49mg/L(23.5 ºC) | [Merck ]
176 | [InChIKey]
RZRPTBIGEANTGU-IRIMSJTPSA-N | [CAS DataBase Reference]
382-45-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Androst-4-ene-3,11,17-trione(382-45-6) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
Androgenic activity;Androgenic steroid | [Uses]
Steroid hormone with weak androgenic effects. | [Definition]
ChEBI: Adrenosterone is a 3-oxo Delta(4)-steroid that is androst-4-ene carrying three oxo-substituents at positions 3, 11 and 17. It has a role as an androgen, a human urinary metabolite, a marine metabolite and an EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor. It is a 3-oxo-Delta(4) steroid, a 17-oxo steroid, an androstanoid and an 11-oxo steroid. It derives from a hydride of an androstane. | [benefits]
Adrenosterone is sold as a dietary supplement since 2007 as a fat loss and muscle gaining supplement. It is thought to be a competitive selective 11βHSD1 inhibitor, which is responsible for activation of cortisol from cortisone. Thus preventing muscle breakdown, and contributing to a majority of its effects. | [storage]
Store at -20°C | [Purification Methods]
Dissolve adrenosterone i n Me2CO, decolorise it with charcoal, filter, add H2O, Me2CO evaporate and the solid is recrystallised from aqueous EtOH. Also recrystallise it from Et2O or Et2O/pentane and dry it at 110o/0.1mm for 2hours. It can be sublimed under high vacuum. [Reichstein Helv Chim Acta 20 953, 979 1937, Mason et al. J Biol Chem 116 267 1936, Beilstein 7 III 4601.] |
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