| Identification | Back Directory | [Name]
caudatin | [CAS]
38395-02-7 | [Synonyms]
caudatin
Caudatin ,98%
Pregn-5-en-20-one,12-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-3,8,14,17-tetrahydroxy-, (3b,12b,14b,17a)-
Pregn-5-en-20-one, 12-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-3,8,14,17-tetrahydroxy-, (3β,12β,14β,17α)-
(3beta,12beta,14beta,17alpha)-12-[[(2E)-3,4-Dimethyl-1-oxo-2-pentenyl]oxy]-3,8,14,17-tetrahydroxypregn-5-en-20-one
[(3S,8S,9R,10R,12R,13S,14R,17R)-17-acetyl-3,8,14,17-tetrahydroxy-10,13-dimethyl-1,2,3,4,7,9,11,12,15,16-decahydrocyclopenta[a]phenanthren-12-yl] (E)-3,4-dimethylpent-2-enoate | [Molecular Formula]
C28H42O7 | [MDL Number]
MFCD09752778 | [MOL File]
38395-02-7.mol | [Molecular Weight]
490.633 |
| Chemical Properties | Back Directory | [Boiling point ]
617.9±55.0 °C(Predicted) | [density ]
1.25 | [storage temp. ]
4°C, protect from light | [solubility ]
DMF:30.0(Max Conc. mg/mL);61.15(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);61.15(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);61.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:7):0.12(Max Conc. mg/mL);0.24(Max Conc. mM) | [form ]
A solid | [pka]
11.93±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
VWLXIXALPNYWFH-NLCMXFOFNA-N | [SMILES]
[C@]12(C)[C@H](OC(=O)/C=C(\C)/C(C)C)C[C@]3([H])[C@@]4(C)CC[C@H](O)CC4=CC[C@@]3(O)[C@@]1(O)CC[C@]2(O)C(C)=O |&1:0,2,13,15,19,25,27,31,r| |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents. | [Uses]
Gaodatin has inhibitory effect on the growth of various human-derived tumor cell lines such as human gastric cancer, colon cancer, and lung cancer. | [Biological Activity]
Caudatin, a C-21 steroid hormone derived from Cynanchum auriculatum (C. auriculatum), potently inhibits human glioma growth in vitro and in vivo by triggering cell cycle arrest and apoptosis. |
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