| Identification | Back Directory | [Name]
Bufotaline | [CAS]
471-95-4 | [Synonyms]
BUFOTALIN
Bufotaline
BUFOTALIN(SH)
Bufotalin std.
Bufotaline ,98%
GAMMA-BUFOTALIN
BUFOTALIN SULFATE
Bufotalin Standard
Bufotaline cas no. 471-95-4
16-(Acetyloxy)-3,14-dihydroxybufa-20,22-dienolide
16β-Acetoxy-3β,14-dihydroxy-5β-bufa-20,22-dienolide
3b,14,16b-Trihydroxy-5b-bufa-20,22-dienolide 16-acetate
16β-Acetyloxy-3β,14-dihydroxy-5β,14β-bufa-20,22-dienolide
3-BETA-14,16-BETA-TRIHYDROXY-5BETA-BUFA-20,22-DIENOLIDE SULFATE
22-dienolide,3-beta,14,16-beta-trihydroxy-5-beta-bufa-216-acetate
20,21,22,23-Tetradehydro-5β-bufanolide-3β,14β,16β-triol 16-acetate
Bufa-20,22-dienolide, 16-(acetyloxy)-3,14-dihydroxy-, (3β,5β,16β)-
5beta-Bufa-20,22-dienolide, 3beta,14,16beta-trihydroxy-, 16-acetate
Bufa-20,22-dienolide, 16-(acetyloxy)-3,14-dihydroxy-, (3beta,5beta,16beta)- | [Molecular Formula]
C26H36O6 | [MDL Number]
MFCD00210248 | [MOL File]
471-95-4.mol | [Molecular Weight]
444.56 |
| Chemical Properties | Back Directory | [Appearance]
Crystalline genin. | [Melting point ]
223°C (rough estimate) | [alpha ]
D20 +5.4° (c = 0.5 in chloroform) | [Boiling point ]
474.53°C (rough estimate) | [density ]
1.0942 (rough estimate) | [refractive index ]
1.4593 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
White to off-white solid. | [pka]
14.44±0.70(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
471-95-4 | [NIST Chemistry Reference]
Bufotalin(471-95-4) |
| Hazard Information | Back Directory | [Chemical Properties]
Crystalline genin. | [Hazard]
Deadly poison. | [Uses]
Bufotalin is a component of Bufo bufo gargarizans which acts as an anti-tumor agent. | [Definition]
ChEBI:Bufotalin is a steroid lactone. It is functionally related to a bufanolide. | [in vivo]
Bufotalin (0.5-1 mg/kg; intraperitoneal injection; twice daily; for 7 days) treatment shows a significantly reduced tumor growth in mice[1]. | Animal Model: | SCID male mice (4-6 weeks old) injected with U2OS cells[1] | | Dosage: | 0.5 mg/kg, 1 mg/kg | | Administration: | Intraperitoneal injection; twice daily; for 7 days | | Result: | Inhibited U2OS osteoblastoma cell growth in mice. |
| [storage]
Store at -20°C |
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