| Identification | Back Directory | [Name]
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide | [CAS]
3854-04-4 | [Synonyms]
CPD3509
Oxotremorine M (iodide)
trimethyl-[4-(2-oxopyrrolidin-1-yl)but-2-ynyl]azanium:iodide | [Molecular Formula]
C11H19IN2O | [MDL Number]
MFCD00055133 | [MOL File]
3854-04-4.mol | [Molecular Weight]
322.186 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
DMSO : 125 mg/mL (387.97 mM; Need ultrasonic) | [form ]
Powder | [color ]
Light yellow to yellow | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Description]
Oxotremorine M is a non-selective muscarinic (M) acetylcholine receptor agonist that induces phosphoinositide hydrolysis in mouse ileum isolated from wild-type, M2, M3, and M2/M3 knockout mice (EC50s = 0.36, 0.52, 1.62, and 1.48 μM, respectively). It also increases M4-induced inhibition of calcium currents in NG108-15 mouse neuroblastoma X rat glioma hybrid cells (EC50 = 0.14 μM). Oxotremorine M inhibits KCNQ2/3 potassium currents in Xenopus oocytes expressing M1 receptors and KCNQ2/3 potassium channels (IC50 = 1.1 μM). It also directly inhibits KCNQ2/3 potassium channels, decreasing KCNQ2/3 potassium currents in Xenopus oocytes lacking muscarinic receptors in a dose-dependent manner. | [Uses]
Oxotremorine M is a muscarinic receptor agonist. | [in vivo]
Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g[4].
| [storage]
Desiccate at -20°C | [References]
[1] JOHN A TRAN F J E Minoru Matsui. Differential coupling of muscarinic M1, M2, and M3 receptors to phosphoinositide hydrolysis in urinary bladder and longitudinal muscle of the ileum of the mouse.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 318 2: 649-656. DOI: 10.1124/jpet.106.103093
[2] M.P. CAULFIELD D. A B. Pharmacology of the putative M4 muscarinic receptor mediating Ca-current inhibition in neuroblastoma × glioma hybrid (NG 108–15) cells[J]. British Journal of Pharmacology, 1991, 104 1: 39-44. DOI: 10.1111/j.1476-5381.1991.tb12381.x
[3] RUUD ZWART. A novel muscarinic receptor-independent mechanism of KCNQ2/3 potassium channel blockade by Oxotremorine-M[J]. European journal of pharmacology, 2016, 791: Pages 221-228. DOI: 10.1016/j.ejphar.2016.08.037 |
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BOC Sciences
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https://www.bocsci.com |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
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https://www.invivochem.cn/ |
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