| Identification | More | [Name]
8-AMINOGUANOSINE | [CAS]
3868-32-4 | [Synonyms]
NSC 90390
8-AMINOGUANOSINE
2,8-DIAMINOINOSINE
Guanosine, 8-amino-
8-Amino-D-guanosine
Adenosine Impurity 24
8-AMINOGUANOSINE USP/EP/BP
2,8-diamino-9-pentofuranosyl-3,9-dihydro-6H-purin-6-one
2,8-diamino-9-[3,4-dihydroxy-5-(hydroxymethyl)-2-oxolanyl]-3H-purin-6-one
2,8-diamino-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
2,8-diamino-9-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)-3H-purin-6-one
2,8-diamino-9-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-purin-6-one
2,8-diamino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
2,8-Diamino-9-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
2,8-diamino-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one | [Molecular Formula]
C10H14N6O5 | [MDL Number]
MFCD00036759 | [Molecular Weight]
298.26 | [MOL File]
3868-32-4.mol |
| Chemical Properties | Back Directory | [Appearance]
Off-White to Tan Solid | [Melting point ]
261°C dec. | [density ]
2.440±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
Aqueous Acid (Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
powder | [pka]
9.025±0.20(predicted) | [color ]
white to brown | [Usage]
A potent inhibitor of purine nucleoside phosphorylas | [InChI]
1S/C10H14N6O5/c11-9-14-6-3(7(20)15-9)13-10(12)16(6)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H2,12,13)(H3,11,14,15,20) | [InChIKey]
FNXPTCITVCRFRK-UHFFFAOYSA-N | [SMILES]
NC1=NC(C2=C(N1)N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N2)=O | [CAS DataBase Reference]
3868-32-4(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Tan Solid | [Uses]
A potent inhibitor of purine nucleoside phosphorylase | [Biological Activity]
8-Aminoguanosinea guanosine derivativeis an orally available and highly efficacious potassium-sparing diuretic/natriuretic th at increased sodium excretion by 26.2-fold and decrease potassium excretion by 69.1%. 8-Aminoguanosine increases glucose excretion by 12.2-fold. Also 8-Aminoguanosine suppressed deoxycorticosterone/salt-induced hypertension.''8-Aminoguanosine is known to stimulate diuresisnatriuresisglucosuria and antikaliuresis. It is an analog of guanosineth at can block purine nucleoside phosphorylasein vitro and in intact lymphoid cells. 8-aminoguanosine triphosphate can be used to block GTP (guanosine triphosphate) cyclohydrolase I from human liver and Escherichia coli. |
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BOC Sciences
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