| Identification | Back Directory | [Name]
CK-0157869 | [CAS]
388592-44-7 | [Synonyms]
CK-869
CK 869
CS-2870
CK-0157869
CK-869; CK 869; CK869; CK-0157869; CK 0157869; CK0157869
2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
4-Thiazolidinone, 2-(3-bromophenyl)-3-(2,4-dimethoxyphenyl)- | [Molecular Formula]
C17H16BrNO3S | [MDL Number]
MFCD01844129 | [MOL File]
388592-44-7.mol | [Molecular Weight]
394.28 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to light gray | [InChI]
1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3 | [InChIKey]
MVWNPZYLNLATCH-UHFFFAOYSA-N | [SMILES]
S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br |
| Hazard Information | Back Directory | [Description]
CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells. It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 μM. It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells. | [Uses]
CK-869 binds to the Arp2/3 complex and inhibits nucleation. The Arp2/3 complex is involved with cell motility and F-actin reorganization in M-1 cells. | [Uses]
CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
- to induce membrane blebbing in HT1080 fibrosarcoma cells
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
| [Biochem/physiol Actions]
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex. | [storage]
Store at -20°C | [References]
[1] DARIA V ILATOVSKAYA. Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells.[J]. Cell and Tissue Research, 2013, 354 3: 783-792. DOI: 10.1007/s00441-013-1710-y
[2] B. J. NOLEN. Characterization of two classes of small molecule inhibitors of Arp2/3 complex[J]. Nature, 2009, 460 7258: 1031-1034. DOI: 10.1038/nature08231
[3] YVONNE BECKHAM. Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.[J]. PLoS ONE, 2014: e100943. DOI: 10.1371/journal.pone.0100943 |
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| Company Name: |
Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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