| Identification | Back Directory | [Name]
CORALYNE CHLORIDE HYDRATE, 98+% | [CAS]
38989-38-7 | [Synonyms]
nsc96349
coralyne chloride crystalline
CORALYNE CHLORIDE HYDRATE, 98+%
8-methyl-2,3,10,11-tetramethoxydibenzo(a,g)quinoliziniumchloride
g)quinolizinium,8-methyl-2,3,10,11-tetramethoxy-dibenzo(chloride
2,3,10,11-tetramethoxy-8-methyldibenzo[a,g]quinolizinium chloride | [EINECS(EC#)]
254-239-2 | [Molecular Formula]
C22H22ClNO4 | [MDL Number]
MFCD00011938 | [MOL File]
38989-38-7.mol | [Molecular Weight]
399.867 |
| Chemical Properties | Back Directory | [Appearance]
orange crystalline powder | [Melting point ]
215°C | [storage temp. ]
2-8°C | [solubility ]
DMSO:5.0(Max Conc. mg/mL);12.5(Max Conc. mM)
Water:5.0(Max Conc. mg/mL);12.5(Max Conc. mM) | [form ]
Solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Chemical Properties]
orange crystalline powder | [Uses]
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage[2]. Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes[3]. | [IC 50]
Topoisomerase I | [storage]
Store at -20°C | [References]
[1] Seema Kumari, et al. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 2017 Jul;91:436-445. DOI:10.1016/j.biopha.2017.04.027
[2] D Makhey, et al. Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons. Bioorg Med Chem. 1996 Jun;4(6):781-91. DOI:10.1016/0968-0896(96)00054-5
[3] P M Pithan, et al. 8-Styryl-substituted coralyne derivatives as DNA binding fluorescent probes.RSC Adv. 2017 Feb 8;7(18):10660-10667. DOI:10.1039/c6ra27684a |
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