| Identification | More | [Name]
6-Methoxyisoquinoline | [CAS]
52986-70-6 | [Synonyms]
6-METHOXY-ISOQUINOLINE
6-Methoxyisoquinoline 90% | [Molecular Formula]
C10H9NO | [MDL Number]
MFCD04114861 | [Molecular Weight]
159.18 | [MOL File]
52986-70-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear Oil | [Boiling point ]
88-95?C/0.8 Torr | [density ]
1.130±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Dichloromethane | [form ]
Oil | [pka]
6.11±0.10(Predicted) | [color ]
Pale Yellow | [InChI]
InChI=1S/C10H9NO/c1-12-10-3-2-9-7-11-5-4-8(9)6-10/h2-7H,1H3 | [InChIKey]
XZNUJESLPUNSNO-UHFFFAOYSA-N | [SMILES]
C1C2=C(C=C(OC)C=C2)C=CN=1 | [CAS DataBase Reference]
52986-70-6(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Oil | [Uses]
6-Methoxy Isoquinoline (cas# 52986-70-6) is a compound useful in organic synthesis. | [Preparation]
6-Methoxyisoquinoline synthesis: Using benzaldehyde as the starting material, m-methoxybenzaldehyde is obtained through nitration, reduction, diazotization, hydrolysis and methylation, and 3-methoxybenzaldehyde is obtained through condensation with nitromethane Shiff base and reduction of aluminum hydride -p-Phenylethylamine. The Pictet-Spengler reaction of 3-methoxyl-p-phenylethylamine and 40% aqueous formaldehyde produces 6-methoxyl-1,2,3,4-tetrahydroisoquinoline, and then obtains the target compound in dehydrogenation 6-Methoxyisoquinoline. | [Synthesis Reference(s)]
Journal of the American Chemical Society, 69, p. 1939, 1947 DOI: 10.1021/ja01200a028 |
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